Evidence map›Paper›PMID 31684879›Full record

ArticleBMC geriatrics2019

Advanced glycation end products and their ratio to soluble receptor are associated with limitations in physical functioning only in women: results from the CARLA cohort.

Helen Ebert, Maria Elena Lacruz, Alexander Kluttig, Andreas Simm, Karin Halina Greiser, Daniel Tiller, Nadja Kartschmit, Rafael Mikolajczyk

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Article
  5. Article
  6. Review
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  8. Article
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  10. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Helen EbertInstitute of medical epidemiology, biometrics and informatics, Medical faculty of the Martin-Luther University Halle, Magdeburger Str. 8, 06112, Halle, Germany.
Maria Elena LacruzInstitute of medical epidemiology, biometrics and informatics, Medical faculty of the Martin-Luther University Halle, Magdeburger Str. 8, 06112, Halle, Germany.
Alexander KluttigInstitute of medical epidemiology, biometrics and informatics, Medical faculty of the Martin-Luther University Halle, Magdeburger Str. 8, 06112, Halle, Germany.
Andreas SimmUniversity Clinic and Outpatient Clinic for Cardiac Surgery,Middle German Heart Centre at the University Hospital Halle, Halle, Germany.
Karin Halina GreiserInstitute of medical epidemiology, biometrics and informatics, Medical faculty of the Martin-Luther University Halle, Magdeburger Str. 8, 06112, Halle, Germany.
Daniel TillerInstitute of medical epidemiology, biometrics and informatics, Medical faculty of the Martin-Luther University Halle, Magdeburger Str. 8, 06112, Halle, Germany.
Nadja KartschmitInstitute of medical epidemiology, biometrics and informatics, Medical faculty of the Martin-Luther University Halle, Magdeburger Str. 8, 06112, Halle, Germany.
Rafael MikolajczykInstitute of medical epidemiology, biometrics and informatics, Medical faculty of the Martin-Luther University Halle, Magdeburger Str. 8, 06112, Halle, Germany. rafael.mikolajczyk@medizin.uni-halle.de.ORCID 0000-0003-1271-7204
Martin Luther University Halle-Wittenberg · DEDeutsches Herzzentrum München · DEGerman Cancer Research Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdvanced glycation end products (AGEs), modifications of proteins or amino acids, are increasingly produced and accumulated with age-related diseases. Recent studies suggested that the ratio of AGEs and their soluble receptor (sRAGE) is a more accurate biomarker for age-related diseases than each separately. We aim to investigate whether this also applies for physical functioning in a broad age-spectrum.

methodsAGE and sRAGE levels, and physical functioning (SF-12 questionnaire) of 967 men and 812 women (45-83 years) were measured in the CARLA study. We used ordinal logistic regression to examine associations between AGEs, sRAGE, and AGE/sRAGE ratio with physical functioning in sex- and age-stratified models.

resultsHigher levels of AGEs and AGE/sRAGE ratio were associated with lower physical functioning only in women, even after consideration of classical lifestyle and age-related factors (education, BMI, smoking, alcohol consumption, diet, creatinine clearance, diabetes mellitus, lipid lowering and antihypertensive drugs) (odds ratio (OR) =0.86, 95%confidence interval = 0.74-0.98 and OR = 0.86, 95%CI = 0.75-0.98 for AGEs and AGE/sRAGE ratio respectively). We could not demonstrate a significant difference across age.

conclusionsWe showed a sex-specific association between physical functioning and AGEs and AGE/sRAGE, but no stronger associations of the latter with physical functioning. Further investigation is needed in the pathophysiology of this association.

Indexed as

Physical Functional PerformanceAgedAgingBiomarkersCohort StudiesFemaleGeriatric AssessmentGermanyGlycation End Products, AdvancedHumansMaleMiddle AgedOdds RatioReceptor for Advanced Glycation End ProductsSex FactorsBiomarkersGlycation End Products, AdvancedReceptor for Advanced Glycation End ProductsAdvanced glycosylationBiomarkerDisabilityPhysical function

Identifiers

PMID31684879
PMCPMC6829799
OpenAlexW2984063906

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.