Evidence map›Paper›PMID 31684770›Full record

ArticleAmyotrophic lateral sclerosis & frontotemporal degeneration2020

Identifying potential targets for prevention and treatment of amyotrophic lateral sclerosis based on a screen of medicare prescription drugs.

Ruth M Pfeiffer, Bernd Mayer, Ralph W Kuncl, David P Check, Elizabeth K Cahoon, Donna R Rivera, D Michal Freedman

Open access · greenAbstract read
In one paragraph

Article in Amyotrophic lateral sclerosis & frontotemporal degeneration, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Medications on hypertension, hyperlipidemia, diabetes, and risk of amyotrophic lateral sclerosis: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022 · on this map
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Prevalence and impact of comorbidities in amyotrophic lateral sclerosis.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  6. Sex Hormones Associate With Amyotrophic Lateral Sclerosis Risk and Survival.Annals of clinical and translational neurology · 2026
    Article
  7. Article
  8. Type 2 diabetes mellitus, antidiabetics, and the risk of amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2025
    Article
  9. Article
  10. Article
  11. Article
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  14. Review
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  18. Article
  19. A roadmap to ALS prevention: strategies and priorities.Journal of neurology, neurosurgery, and psychiatry · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Ruth M PfeifferNational Cancer Institute, Division of Cancer Epidemiology and Genetics, NIH, DHHS, Bethesda, MD, USA.
Bernd MayerInstitute of Pharmaceutical Sciences, Department of Pharmacology and Toxicology, University of Graz, Graz, Austria.
Ralph W KunclDepartment of Biology, University of the Redlands, Redlands, CA, USA, and.
David P CheckNational Cancer Institute, Division of Cancer Epidemiology and Genetics, NIH, DHHS, Bethesda, MD, USA.
Elizabeth K CahoonNational Cancer Institute, Division of Cancer Epidemiology and Genetics, NIH, DHHS, Bethesda, MD, USA.
Donna R RiveraNational Cancer Institute, Division of Cancer Control and Population Sciences, NIH, DHHS, Bethesda, MD, USA.
D Michal FreedmanNational Cancer Institute, Division of Cancer Epidemiology and Genetics, NIH, DHHS, Bethesda, MD, USA.
National Cancer Institute · USUnited States Department of Health and Human Services · USDivision of Cancer Epidemiology and GeneticsUniversity of Graz · ATUniversity of Redlands · US

Funding

Infections, immunity, and inflammation in cancerZIACP010150 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ENGELS, ERIC A · 2009 to 2025
$24.0M
Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedAged, 80 and overAmyotrophic Lateral SclerosisAnti-Bacterial AgentsAntihypertensive AgentsCase-Control StudiesFemaleHumansHypoglycemic AgentsMaleMedicareMedicare Part DPrescription DrugsUnited StatesAnti-Bacterial AgentsAntihypertensive AgentsHypoglycemic AgentsPrescription DrugsAmyotrophic lateral sclerosisdrug screeningMedicaremedicationspopulation basedrisk

Identifiers

PMID31684770
PMCPMC9930913
OpenAlexW2983948195

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.