ArticleJournal of clinical medicine2019
Osteoarthritis Severely Decreases the Elasticity and Hardness of Knee Joint Cartilage: A Nanoindentation Study.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Ex Vivo Differentiation of Cartilage Degeneration Severity and Subchondral Bone Using Vibroacoustic Signals from Instrument-Tissue Interaction.Sensors (Basel, Switzerland) · 2026Article
- Mechanical Signatures of Tibiofemoral Cartilage Degeneration Identified by Unconfined Compression Testing: Implications for Early Osteoarthritis Risk in Athletes.Medicina (Kaunas, Lithuania) · 2026Article
- Reduced cartilage matrix stiffness in temporomandibular joint osteoarthritis impairs the functions of superficial zone chondrocytes via downregulation of CREB5-PLPP3 signaling.Molecular biomedicine · 2026Article
- Identification of ERN1 as a Potential Context-Dependent Biomarker in Chronic Obstructive Pulmonary Disease Based on Bioinformatics Analysis of GSE57148 Dataset.International journal of chronic obstructive pulmonary disease · 2026Article
- Assessing sensitivity of predictive shoulder simulations to uncertain soft tissue properties.Journal of biomechanics · 2026Article
- Moxibustion Regulates Amino Acid Metabolism Pathways to Improve Cartilage Damage in Knee Osteoarthritis Model Rats.Cureus · 2025Article
- Article
- Biomechanical properties of articular cartilage in different regions and sites of the knee joint: acquisition of osteochondral allografts.Cell and tissue banking · 2024Article
- Pathological progression of osteoarthritis: a perspective on subchondral bone.Frontiers of medicine · 2024Review
- Role of mechanically-sensitive cation channels Piezo1 and TRPV4 in trabecular meshwork cell mechanotransduction.Human cell · 2024Review
- Early Degenerative Changes in a Spontaneous Osteoarthritis Model Assessed by Nanoindentation.Bioengineering (Basel, Switzerland) · 2023Article
- Biomechanical Characteristics and Analysis Approaches of Bone and Bone Substitute Materials.Journal of functional biomaterials · 2023Review
- Structural clues to articular calcified cartilage function: A descriptive review of this crucial interface tissue.Journal of anatomy · 2022Review
- Article
- The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis.Frontiers in cell and developmental biology · 2022Review
- Serum and synovial fluid concentrations of interleukin-18 and interleukin-20 in patients with osteoarthritis of the knee and their correlation with other markers of inflammation and turnover of joint cartilage.Archives of medical science : AMS · 2022Article
- Tuning the Properties of PNIPAm-Based Hydrogel Scaffolds for Cartilage Tissue Engineering.Polymers · 2021Review
- Early Detection of Cartilage Degeneration: A Comparison of Histology, Fiber Bragg Grating-Based Micro-Indentation, and Atomic Force Microscopy-Based Nano-Indentation.International journal of molecular sciences · 2020Article
- Carbon Nanotubes Interference with Luminescence-Based Assays.Materials (Basel, Switzerland) · 2020Article
- Utilization of Carbon Nanotubes in Manufacturing of 3D Cartilage and Bone Scaffolds.Materials (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The nanoindentation method was applied to determine the elastic modulus and hardness of knee articular cartilage. Cartilage samples from both high weight bearing (HWB) and low weight bearing (LWB) femoral condyles were collected from patients diagnosed with osteoarthritis (OA). The mean elastic modulus of HWB cartilage was 4.46 ± 4.44 MPa in comparison to that of the LWB region (9.81 ± 8.88 MPa,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.