ArticleNutrients2019
Berry-Enriched Diet in Salt-Sensitive Hypertensive Rats: Metabolic Fate of (Poly)Phenols and the Role of Gut Microbiota.
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
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Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Plasma and Urinary Metabolomic Profiles Associated with the Salt Sensitivity of Blood Pressure in the Dietary Approaches to Stop Hypertension-Sodium Trial.The Journal of nutrition · 2026Trial
- Trial
- Longitudinal integration of microbiota and metabolomics reveals (poly)phenols-driven gut ecosystem dynamics.Frontiers in nutrition · 2026Article
- Associations Between Gut Microbiota, Short-Chain Fatty Acids, and High-Salt Diet-Induced Hypertension in Rats.Current medical science · 2025Article
- Dynamic Microbiome Responses to Structurally Diverse Anthocyanin-Rich Foods in a Western Diet Context.Nutrients · 2025Article
- Dietary Polyphenol, Gut Microbiota, and Health Benefits.Antioxidants (Basel, Switzerland) · 2022Review
- Time series analysis of short-term effects of particulate matter pollution on the circulatory system disease mortality risk in Lishui District, China.Environmental science and pollution research international · 2022Article
- Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies.Oxidative medicine and cellular longevity · 2021Review
- The Role of Histone Acetylation and the Microbiome in Phytochemical Efficacy for Cardiovascular Diseases.International journal of molecular sciences · 2020Review
- Increasing Doses of Blueberry Polyphenols Alters Colonic Metabolism and Calcium Absorption in Ovariectomized Rats.Molecular nutrition & food research · 2020Article
- Polyphenol-Rich Foods for Human Health and Disease.Nutrients · 2020Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 6 countries.
Funding
Abstract
Diets rich in (poly)phenols are associated with a reduced reduction in the incidence of cardiovascular disorders. While the absorption and metabolism of (poly)phenols has been described, it is not clear how their metabolic fate is affected under pathological conditions. This study evaluated the metabolic fate of berry (poly)phenols in an in vivo model of hypertension as well as the associated microbiota response. Dahl salt-sensitive rats were fed either a low-salt diet (0.26% NaCl) or a high-salt diet (8% NaCl), with or without a berry mixture (blueberries, blackberries, raspberries, Portuguese crowberry and strawberry tree fruit) for 9 weeks. The salt-enriched diet promoted an increase in the urinary excretion of berry (poly)phenol metabolites, while the abundance of these metabolites decreased in faeces, as revealed by UPLC-MS/MS. Moreover, salt and berries modulated gut microbiota composition as demonstrated by 16S rRNA analysis. Some changes in the microbiota composition were associated with the high-salt diet and revealed an expansion of the families
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Registered trials
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