Evidence map›Paper›PMID 31684141›Full record

ArticleInternational journal of molecular sciences2019

Metabolic Profile, Bioavailability and Toxicokinetics of Zearalenone-14-Glucoside in Rats after Oral and Intravenous Administration by Liquid Chromatography High-Resolution Mass Spectrometry and Tandem Mass Spectrometry.

Feifei Sun, Haiguang Tan, Yanshen Li, Marthe De Boevre, Sarah De Saeger, Jinhui Zhou, Yi Li, Zhenghua Rao, Shupeng Yang, Huiyan Zhang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  7. AnToxicology reports · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Feifei SunInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China. sunff@ahau.edu.cn.
Haiguang TanInstitute of Apicultural Research, Chinese Academy of Agricultural Sciences, Key Laboratory of Bee Products for Quality and Safety Control, Bee Product Quality Supervision and Testing Center, Ministry of Agriculture, Beijing 100093, China. tanhaiguang1994@foxmail.com.
Yanshen LiCollege of Life Science, Yantai University, Yantai 264005, China. liyanshen@tyu.edu.cn.
Marthe De BoevreCentre of Excellence in Mycotoxicology and Public Health, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Marthe.DeBoevre@UGent.be.ORCID 0000-0002-6151-5126
Sarah De SaegerCentre of Excellence in Mycotoxicology and Public Health, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Sarah.DeSaeger@UGent.be.ORCID 0000-0002-2160-7253
Jinhui ZhouInstitute of Apicultural Research, Chinese Academy of Agricultural Sciences, Key Laboratory of Bee Products for Quality and Safety Control, Bee Product Quality Supervision and Testing Center, Ministry of Agriculture, Beijing 100093, China. zhoujinhui@caas.cn.
Yi LiInstitute of Apicultural Research, Chinese Academy of Agricultural Sciences, Key Laboratory of Bee Products for Quality and Safety Control, Bee Product Quality Supervision and Testing Center, Ministry of Agriculture, Beijing 100093, China. liiy01@caas.cn.
Zhenghua RaoInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China. raozhenghua@caas.cn.
Shupeng YangInstitute of Apicultural Research, Chinese Academy of Agricultural Sciences, Key Laboratory of Bee Products for Quality and Safety Control, Bee Product Quality Supervision and Testing Center, Ministry of Agriculture, Beijing 100093, China. yangshupeng@caas.cn.
Huiyan ZhangInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China. zhanghuiyan0606@126.com.
Chinese Academy of Agricultural Sciences · CNYantai University · CNGhent University · BEAnhui Agricultural University · CN

Funding

National Natural Science Foundation of China No.31702296National Natural Science Foundation of China No.31871718
6 · The paper itself

Abstract

Zearalenone-14-glucoside (ZEN-14G), a key modified mycotoxin, has attracted a great deal of attention due to the possible conversion to its free form of zearalenone (ZEN) exerting toxicity. In this study, the toxicokinetics of ZEN-14G were investigated in rats after oral and intravenous administration. The plasma concentrations of ZEN-14G and its major five metabolites were quantified using a validated liquid chromatography tandem mass spectrometry (LC-MS/MS) method. The data were analyzed via non-compartmental analysis using software WinNonlin 6.3. The results indicated that ZEN-14G was rapidly hydrolyzed into ZEN in vivo. In addition, the major parameters of ZEN-14G following intravenous administration were: area under the plasma concentration-time curve (AUC), 1.80 h·ng/mL; the apparent volume of distribution (V

Indexed as

MetabolomeAdministration, IntravenousAdministration, OralAnimalsBiological AvailabilityChromatography, LiquidFemaleGlucosidesMaleMass SpectrometryMetabolomicsMycotoxinsRats, WistarTandem Mass SpectrometryToxicokineticsZearalenoneGlucosidesMycotoxinsZearalenonezearalenone-14-glucosidebioavailabilitymasked mycotoxinsmetabolismrisk assessmentzearalenone

Identifiers

PMID31684141
PMCPMC6862289
OpenAlexW2983351372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.