Evidence map›Paper›PMID 31683978›Full record

ReviewInternational journal of molecular sciences2019

Monocytic Myeloid Derived Suppressor Cells in Hematological Malignancies.

Giuseppe Alberto Palumbo, Nunziatina Laura Parrinello, Cesarina Giallongo, Emanuele D'Amico, Aurora Zanghì, Fabrizio Puglisi, Concetta Conticello, Annalisa Chiarenza, Daniele Tibullo, Francesco Di Raimondo and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 30 citations in OpenAlex.

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  17. The follicular lymphoma epigenome regulates its microenvironment.Journal of experimental & clinical cancer research : CR · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Giuseppe Alberto PalumboDivision of Hematology, AOU "Policlinico-Vittorio Emanuele", 95125 Catania, Italy. palumbo.ga@gmail.com.
Nunziatina Laura ParrinelloDivision of Hematology, AOU "Policlinico-Vittorio Emanuele", 95125 Catania, Italy. lauraparrinello@tiscali.it.
Cesarina GiallongoDivision of Hematology, AOU "Policlinico-Vittorio Emanuele", 95125 Catania, Italy. cesarinagiallongo@yahoo.it.
Emanuele D'AmicoDepartment of Clinical and Molecular Biomedicine Ingrassia, University of Catania, 95125 Catania, Italy. puglisi.fabri@gmail.com.
Aurora ZanghìDepartment of Clinical and Molecular Biomedicine Ingrassia, University of Catania, 95125 Catania, Italy. aurora.zanghi@yahoo.it.
Fabrizio PuglisiDivision of Hematology, AOU "Policlinico-Vittorio Emanuele", 95125 Catania, Italy. puglisi.fabri@gmail.com.
Concetta ConticelloDivision of Hematology, AOU "Policlinico-Vittorio Emanuele", 95125 Catania, Italy. ettaconticello@gmail.com.
Annalisa ChiarenzaDivision of Hematology, AOU "Policlinico-Vittorio Emanuele", 95125 Catania, Italy. annalisa.chiarenza@gmail.com.
Daniele TibulloBIOMETEC, Dipartimento di Scienze Biomediche e Biotecnologiche, University of Catania, 95125 Catania, Italy. danieletibullo@gmail.com.
Francesco Di RaimondoDivision of Hematology, AOU "Policlinico-Vittorio Emanuele", 95125 Catania, Italy. diraimon@unict.it.
Alessandra RomanoDivision of Hematology, AOU "Policlinico-Vittorio Emanuele", 95125 Catania, Italy. sandrina.romano@gmail.com.
University of Catania · ITAzienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the era of novel agents and immunotherapies in solid and liquid tumors, there is an emerging need to understand the cross-talk between the neoplastic cells, the host immune system, and the microenvironment to mitigate proliferation, survival, migration and resistance to drugs. In the microenvironment of hematological tumors there are cells belonging to the normal bone marrow, extracellular matrix proteins, adhesion molecules, cytokines, and growth factors produced by both stromal cells and neoplastic cells themselves. In this context, myeloid suppressor cells are an emerging sub-population of regulatory myeloid cells at different stages of differentiation involved in cancer progression and chronic inflammation. In this review, monocytic myeloid derived suppressor cells and their potential clinical implications are discussed to give a comprehensive vision of their contribution to lymphoproliferative and myeloid disorders.

Indexed as

AnimalsBone Marrow CellsCell CommunicationCell DifferentiationDisease ProgressionHematologic NeoplasmsHumansMonocytesMyeloid-Derived Suppressor CellsStromal CellsTumor Microenvironmentchronic lymphatic leukemiachronic myeloid leukemialymphoma MDSCmicroenvironmentmultiple myeloma

Identifiers

PMID31683978
PMCPMC6862591
OpenAlexW2985066828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.