Evidence map›Paper›PMID 31683936›Full record

ArticleCells2019

Alternative Splicing of RAD6B and Not RAD6A is Selectively Increased in Melanoma: Identification and Functional Characterization.

Ambikai Gajan, Carly E Martin, Seongho Kim, Milap Joshi, Sharon K Michelhaugh, Ido Sloma, Sandeep Mittal, Steven Firestine, Malathy P V Shekhar

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ambikai GajanKarmanos Cancer Institute, Detroit, MI 48201, USA. gajana@karmanos.org.
Carly E MartinKarmanos Cancer Institute, Detroit, MI 48201, USA. carly.martin@wayne.edu.
Seongho KimKarmanos Cancer Institute, Detroit, MI 48201, USA. kimse@karmanos.org.
Milap JoshiKarmanos Cancer Institute, Detroit, MI 48201, USA. milap.joshi.5000@gmail.com.
Sharon K MichelhaughKarmanos Cancer Institute, Detroit, MI 48201, USA. skmichel@vtc.vt.edu.
Ido SlomaChampions Oncology, Rockville, MD 20850, USA. isloma@championsoncology.com.
Sandeep MittalKarmanos Cancer Institute, Detroit, MI 48201, USA. sandeepmittal@vt.edu.
Steven FirestinePharmaceutical Sciences, Wayne State University, Detroit, MI 48201, USA. sfirestine@wayne.edu.
Malathy P V ShekharKarmanos Cancer Institute, Detroit, MI 48201, USA. shekharm@karmanos.org.
The Barbara Ann Karmanos Cancer Institute · USWayne State University · USChampions Oncology (United States) · US

Funding

TRAINING PROGRAM IN THE BIOLOGY OF CANCERT32CA009531 · NCI · WAYNE STATE UNIVERSITY · PI Larry H Matherly · 1985 to 2026
$5.3M
Targeting Rad6 Postreplication DNA Repair to Treat Triple Negative Breast CancerR21CA178117 · NCI · WAYNE STATE UNIVERSITY · PI SHEKHAR, MALATHY PV · 2013 to 2015
$358k
NCI NIH HHS R21 CA178117NCI NIH HHS T32 CA009531
6 · The paper itself

Abstract

Rad6B, a principal component of the translesion synthesis pathway, and activator of canonical Wnt signaling, plays an essential role in cutaneous melanoma development and progression. As Rad6 is encoded by two genes, namely,

Indexed as

AdultAgedAged, 80 and overAlternative Splicingbeta CateninCell LineCutaneous Malignant MelanomaDNA RepairDNA ReplicationExome SequencingFemaleHumansMaleMelanomaMiddle AgedSkin Neoplasmsbeta CateninCTNNB1 protein, humanUBE2A protein, humanUBE2B protein, humanUbiquitin-Conjugating Enzymesalternative splicingexon skippinghistone ubiquitinationmelanomawhole exome sequencing

Identifiers

PMID31683936
PMCPMC6912459
OpenAlexW2988946731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.