Evidence map›Paper›PMID 31683863›Full record

ArticlePharmaceutics2019

Evaluation of Electrospun Poly(ε-Caprolactone)/Gelatin Nanofiber Mats Containing Clove Essential Oil for Antibacterial Wound Dressing.

Irem Unalan, Stefan J Endlein, Benedikt Slavik, Andrea Buettner, Wolfgang H Goldmann, Rainer Detsch, Aldo R Boccaccini

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 125 citations in OpenAlex.

  1. Article
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  5. Review
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  7. Review
  8. Release Profile and Antibacterial Activity ofBioengineering (Basel, Switzerland) · 2025
    Article
  9. Frontiers in microbiology · 2025
    Review
  10. Development of Nanofiber Mats Impregnated WithInternational journal of biomaterials · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
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  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Irem UnalanInstitute of Biomaterials, Department of Materials Science and Engineering, Friedrich-Alexander-University Erlangen-Nuremberg, Cauerstraße 6, 91058 Erlangen, Germany. irem.unalan@fau.de.ORCID 0000-0002-4729-0012
Stefan J EndleinInstitute of Biomaterials, Department of Materials Science and Engineering, Friedrich-Alexander-University Erlangen-Nuremberg, Cauerstraße 6, 91058 Erlangen, Germany. stefan.endlein@fau.de.
Benedikt SlavikChair of Aroma and Smell Research, Department of Chemistry and Pharmacy, Friedrich-Alexander-University Erlangen-Nuremberg, Henkestraße 9, 91054 Erlangen, Germany. benedikt.slavik@fau.de.ORCID 0000-0002-6237-8012
Andrea BuettnerChair of Aroma and Smell Research, Department of Chemistry and Pharmacy, Friedrich-Alexander-University Erlangen-Nuremberg, Henkestraße 9, 91054 Erlangen, Germany. andrea.buettner@fau.de.ORCID 0000-0002-6205-5125
Wolfgang H GoldmannInstitute of Biophysics, Department of Physics, Friedrich-Alexander-University Erlangen-Nuremberg, Henkestraße 91, 91052 Erlangen, Germany. wgoldmannh@aol.com.
Rainer DetschInstitute of Biomaterials, Department of Materials Science and Engineering, Friedrich-Alexander-University Erlangen-Nuremberg, Cauerstraße 6, 91058 Erlangen, Germany. Rainer.Detsch@fau.de.
Aldo R BoccacciniInstitute of Biomaterials, Department of Materials Science and Engineering, Friedrich-Alexander-University Erlangen-Nuremberg, Cauerstraße 6, 91058 Erlangen, Germany. aldo.boccaccini@ww.uni-erlangen.de.ORCID 0000-0002-7377-2955
Friedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

Deutscher Akademischer Austauschdienst Section ST21-91652927
6 · The paper itself

Abstract

The objective of this study was to produce antibacterial poly(ε-caprolactone) (PCL)-gelatin (GEL) electrospun nanofiber mats containing clove essential oil (CLV) using glacial acetic acid (GAA) as a "benign" (non-toxic) solvent. The addition of CLV increased the fiber diameter from 241 ± 96 to 305 ± 82 nm. Aside from this, the wettability of PCL-GEL nanofiber mats was increased by the addition of CLV. Fourier-transform infrared spectroscopy (FTIR) analysis confirmed the presence of CLV, and the actual content of CLV was determined by gas chromatography-mass spectrometry (GC-MS). Our investigations showed that CLV-loaded PCL-GEL nanofiber mats did not have cytotoxic effects on normal human dermal fibroblast (NHDF) cells. On the other hand, the fibers exhibited antibacterial activity against

Indexed as

antibacterialbiocompatibilityclove essential oilelectrospinninggelatinPCL

Identifiers

PMID31683863
PMCPMC6920971
OpenAlexW2983302927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.