Evidence map›Paper›PMID 31683764›Full record

ReviewMolecules (Basel, Switzerland)2019

Medically Useful Plant Terpenoids: Biosynthesis, Occurrence, and Mechanism of Action.

Matthew E Bergman, Benjamin Davis, Michael A Phillips

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers.

0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

159 citing papers in PubMed, 371 citations in OpenAlex.

  1. Review
  2. Bioactive compounds fromBiochemistry and biophysics reports · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. The Metabolome of theJournal of natural products · 2026
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Leveraging metabolic similarity in aScientific reports · 2026
    Article
  20. Article

99 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Matthew E BergmanDepartment of Cellular and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada. matthew.bergman@mail.utoronto.ca.ORCID 0000-0002-4071-3166
Benjamin DavisDepartment of Cellular and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada. benjamin.davis@mail.utoronto.ca.
Michael A PhillipsDepartment of Cellular and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada. michaelandrew.phillips@utoronto.ca.ORCID 0000-0001-7276-119X
University of Toronto · CA

Funding

Natural Sciences and Engineering Research Council of Canada RGPIN-2017-06400
6 · The paper itself

Abstract

Specialized plant terpenoids have found fortuitous uses in medicine due to their evolutionary and biochemical selection for biological activity in animals. However, these highly functionalized natural products are produced through complex biosynthetic pathways for which we have a complete understanding in only a few cases. Here we review some of the most effective and promising plant terpenoids that are currently used in medicine and medical research and provide updates on their biosynthesis, natural occurrence, and mechanism of action in the body. This includes pharmacologically useful plastidic terpenoids such as

Indexed as

Biosynthetic PathwaysAnimalsCannabinoidsDiterpenesErythritolHerbal MedicineHumansMevalonic AcidMonoterpenesPaclitaxelSugar PhosphatesTerpenesThapsigargin2-C-methylerythritol 4-phosphate3-ingenyl angelateCannabinoidsDiterpenesErythritolMevalonic AcidMonoterpenesPaclitaxelSugar PhosphatesTerpenesThapsigargincytochrome P450sisoprenoidsmedicinal plantsplant natural productsterpene synthasesterpenoid biosynthesis

Identifiers

PMID31683764
PMCPMC6864776
OpenAlexW2987822484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.