Evidence map›Paper›PMID 31683699›Full record

ArticleMolecules (Basel, Switzerland)2019

Synthesis, Antitumor Activity, and Docking Analysis of New Pyrido[3',2':4,5]furo(thieno)[3,2-

Samvel N Sirakanyan, Domenico Spinelli, Athina Geronikaki, Elmira K Hakobyan, Harutyun Sahakyan, Erik Arabyan, Hovakim Zakaryan, Lusine E Nersesyan, Anahit S Aharonyan, Irina S Danielyan and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Thieno[3,2-International journal of molecular sciences · 2026
    Review
  2. Design, synthesis, andRSC advances · 2025
    Article
  3. Synthesis of 1-Amino-3-oxo-2,7-naphthyridinesInternational journal of molecular sciences · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Samvel N SirakanyanScientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of Science of Republic of Armenia, Institute of Fine Organic Chemistry of A.L. Mnjoyan, Yerevan 0014, Armenia. shnnr@mail.ru.
Domenico SpinelliDipartimento di Chimica G. Ciamician, Alma Mater Studiorum-Università di Bologna, Via F. Selmi 2, 40126 Bologna, Italy. domenico.spinelli@unibo.it.
Athina GeronikakiSchool of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. geronik@pharm.auth.gr.
Elmira K HakobyanScientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of Science of Republic of Armenia, Institute of Fine Organic Chemistry of A.L. Mnjoyan, Yerevan 0014, Armenia. hakobyan.elmira@mail.ru.
Harutyun SahakyanDepartment of Bioengineering, Bioinformatics and Molecular Biology, Russian-Armenian University, Yerevan 0051, Armenia. sahakyanhk@gmail.com.
Erik ArabyanInstitute of Molecular Biology of NAS, Hasratyan 7, Yerevan 0014, Armenia. ear20@mail.ru.
Hovakim ZakaryanInstitute of Molecular Biology of NAS, Hasratyan 7, Yerevan 0014, Armenia. h_zakaryan@mb.sci.am.
Lusine E NersesyanScientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of Science of Republic of Armenia, Institute of Fine Organic Chemistry of A.L. Mnjoyan, Yerevan 0014, Armenia. lusinenersesyan@gmail.com.
Anahit S AharonyanScientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of Science of Republic of Armenia, Institute of Fine Organic Chemistry of A.L. Mnjoyan, Yerevan 0014, Armenia. AAaharonyan@gmail.com.
Irina S DanielyanScientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of Science of Republic of Armenia, Institute of Fine Organic Chemistry of A.L. Mnjoyan, Yerevan 0014, Armenia. irina_danielyan@mail.ru.
Rafayel E MuradyanScientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of Science of Republic of Armenia, Institute of Fine Organic Chemistry of A.L. Mnjoyan, Yerevan 0014, Armenia. muradyanraf@inbox.ru.
Anush A HovakimyanScientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of Science of Republic of Armenia, Institute of Fine Organic Chemistry of A.L. Mnjoyan, Yerevan 0014, Armenia. aaa.h.87@mail.ru.
Institute of Fine Organic Chemistry of Scientific - Technological Center of Organic and Pharmaceutical Chemistry · AMAristotle University of Thessaloniki · GRH.Buniatian Institute of Biochemistry · AMInstitute of Chemical Physics NAS RA · AMRussian-Armenian University · AMUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Continuing our research in the field of new heterocyclic compounds, herein we report on the synthesis and antitumor activity of new amino derivatives of pyrido[3',2':4,5](furo)thieno[3,2-

Indexed as

Molecular Docking SimulationAminesAnimalsAntineoplastic AgentsCarbon-13 Magnetic Resonance SpectroscopyChlorocebus aethiopsHeLa CellsHumansProton Magnetic Resonance SpectroscopyPyridinesThermodynamicsVero CellsAminesAntineoplastic AgentsPyridinesaminationantitumor activityDNA methylationfuro[2,3-e]imidazo[1,2-c]pyrimidinefuro[2,3-e]pyrimido[1,2-c]pyrimidinepyrido[3’,2’:4,5]furo(thieno)[3,2-d]pyrimidin-8-aminessarcoma 180

Identifiers

PMID31683699
PMCPMC6864781
OpenAlexW2982620536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.