Evidence map›Paper›PMID 31683325›Full record

ArticleAmerican journal of perinatology2021

Subfoveal Choroidal Thickness and Associated Changes of Angiogenic Factors in Women with Severe Preeclampsia.

Conrad N Stern-Ascher, Victoria S North, Aakriti Garg, Cande V Ananth, Ronald J Wapner, Srilaxmi Bearelly

Abstract read
In one paragraph

Article in American journal of perinatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Correlation of Ocular Plane-Wave Doppler With Optical Coherence Tomography Angiography in Preeclampsia.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2023
    Article
  4. Article
  5. Article
  6. Plane-Wave Ultrasound Doppler of the Eye in Preeclampsia.Translational vision science & technology · 2020
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Conrad N Stern-AscherDepartment of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York.
Victoria S NorthDepartment of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
Aakriti GargDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University, New York.
Cande V AnanthDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Division of Epidemiology and Biostatistics, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.
Ronald J WapnerDepartment of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York.
Srilaxmi BearellyDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University, New York.

Funding

Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
NCATS NIH HHS UL1 TR000040
6 · The paper itself

Abstract

objectiveSevere preeclampsia complicates roughly 1% of all pregnancies. One defining feature of severe preeclampsia is new onset visual disturbance. The accessibility of the choroid to high-resolution, noninvasive imaging makes it a reasonable target of investigation for disease prediction, stratification, or monitoring in preeclampsia. This study aimed to compare subfoveal choroidal thickness between women with severe preeclampsia and those with normotensive pregnancies, and to investigate associations between such findings and other indicators of disease severity, including gestational age and serum angiogenic factors. STUDY

designWe designed a case-control study comprised of 36 women diagnosed with severe preeclampsia (cases) matched to 37 normotensive women (controls) by race/ethnicity and parity, all diagnosed in the postpartum period. All patients underwent enhanced depth imaging spectral-domain optical coherence tomography and serum analysis.

resultsCases showed no difference in subfoveal choroidal thickness compared with controls (

conclusionThis study suggests a relationship between the degree of disease severity and the magnitude of choroidal thickening. We also show an association between this index and placental growth factor level in the postpartum period.

Indexed as

AdultCase-Control StudiesChoroidFemaleHumansLinear ModelsPlacenta Growth FactorPostpartum PeriodPre-EclampsiaPregnancySeverity of Illness IndexTomography, Optical CoherencePlacenta Growth Factor

Identifiers

PMID31683325
PMCPMC10895649

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.