Evidence map›Paper›PMID 31682938›Full record

ReviewBiochimica et biophysica acta. Gene regulatory mechanisms

Intronic RNA: Ad'junk' mediator of post-transcriptional gene regulation.

Christopher R Neil, William G Fairbrother

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta. Gene regulatory mechanisms. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. PlantIntronDB: a database for plant introns that host functional elements.Database : the journal of biological databases and curation · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. RNA structure and splicing regulation.Biochimica et biophysica acta. Gene regulatory mechanisms
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christopher R NeilMolecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, United States of America.
William G FairbrotherMolecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, United States of America; Center for Computational Molecular Biology, Brown University, Providence, RI, United States of America. Electronic address: william_fairbrother@brown.edu.

Funding

Discovering Splicing Defects in Human GenesR01GM127472 · NIGMS · BROWN UNIVERSITY · PI William G Fairbrother · 2018 to 2026
$5.9M
A genomic approach to studying the life cycle of intron lariatsR01GM105681 · NIGMS · BROWN UNIVERSITY · PI FAIRBROTHER, WILLIAM G · 2014 to 2022
$3.7M
NIGMS NIH HHS R01 GM105681NIGMS NIH HHS R01 GM127472
6 · The paper itself

Abstract

RNA splicing, the process through which intervening segments of noncoding RNA (introns) are excised from pre-mRNAs to allow for the formation of a mature mRNA product, has long been appreciated for its capacity to add complexity to eukaryotic proteomes. However, evidence suggests that the utility of this process extends beyond protein output and provides cells with a dynamic tool for gene regulation. In this review, we aim to highlight the role that intronic RNA plays in mediating specific splicing outcomes in pre-mRNA processing, as well as explore an emerging class of stable intronic sequences that have been observed to act in gene expression control. Building from underlying flexibility in both sequence and structure, intronic RNA provides mechanisms for post-transcriptional gene regulation that are amenable to the tissue and condition specific needs of eukaryotic cells. This article is part of a Special Issue entitled: RNA structure and splicing regulation edited by Francisco Baralle, Ravindra Singh and Stefan Stamm.

Indexed as

Alternative SplicingAnimalsGene Expression RegulationHumansIntronsRNA, MessengerRNA PrecursorsRNA Processing, Post-TranscriptionalRNA, MessengerRNA Precursors

Identifiers

PMID31682938
PMCPMC7171924

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.