Evidence map›Paper›PMID 31682898›Full record

ArticleJournal of dentistry2019

Enhancing the detection of proximal cavities on near infrared transillumination images with Indocyanine Green (ICG) as a contrast medium: In vitro proof of concept studies.

Marwa Abdelaziz, Ivo Krejci, Daniel Fried

Open access · greenAbstract read
In one paragraph

Article in Journal of dentistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Marwa AbdelazizDivision of Cariology and Endodontology, University Clinics of Dental Medicine (CUMD), University of Geneva, Rue Michel-Servet 1, 1211 Geneva 4, Switzerland; Division Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, University of California, 707 Parnassus Ave., San Francisco, CA 94143-0758, USA. Electronic address: Marwa.abdel@unige.ch.
Ivo KrejciDivision of Cariology and Endodontology, University Clinics of Dental Medicine (CUMD), University of Geneva, Rue Michel-Servet 1, 1211 Geneva 4, Switzerland. Electronic address: Ivo.krejci@unige.ch.
Daniel FriedDivision Biomaterials and Bioengineering, Department of Preventive and Restorative Dental Sciences, University of California, 707 Parnassus Ave., San Francisco, CA 94143-0758, USA. Electronic address: Daniel.fried@ucsf.edu.
University of Geneva · CHUniversity of California, San Francisco · US

Funding

Optical Methods for Lesion Activity AssessmentR01DE027335 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRIED, DANIEL · 2018 to 2022
$1.9M
Imaging Dental Caries with SWIR LightR01DE028295 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRIED, DANIEL · 2019 to 2023
$1.9M
NIDCR NIH HHS R01 DE027335NIDCR NIH HHS R01 DE028295
6 · The paper itself

Abstract

objectivesThe use of near infrared transillumination for caries detection is gaining recognition in daily practice. Differentiation between cavitated and non cavitated proximal lesions is recognized as a threshold for restorative treatment. This investigation focused on the use of a near infrared absorbent dye which may enhance the detection of cavitation on near infrared transillumination images. MATERIALS AND

methods1: Natural teeth with artificial proximal cavitation were images with 3 different dyes to establish that near infrared absorbent dye can act like a contrast medium. 2: Natural teeth with natural cavitated lesions were used to investigate the contrast enhancing effect of indocyanine green (ICG) on near infrared transillumination images. 3: Artificial teeth with artificial cavitations were used to determine the best consistency of ICG as a contrast medium. 4: natural teeth with proximal lesions were used to confirm that ICG can differentiate between cavitated and non cavitated proximal lesions.

results1: ICG enhanced the contrast of cavitations compared to other dyes (ANOVA; p < 0.05). 2: ICG enhanced the contrast of the cavitated area on natural lesions but not significantly (t-test; p > 0.05). 3: ICG in a gel form enhanced the detection of cavitated lesions when compared to liquid ICG (t-test; p < 0.05). 4: ICG gel was able to differentiate between cavitated and non cavitated proximal lesions (ANOVA; p < 0.05).

conclusionICG can potentially be used as a contrast medium to enhance the detection of cavitated proximal lesions in vitro on near infrared transillumination images. A clinical study is required to validate these results in vivo.

Indexed as

Proof of Concept StudyTransilluminationDental CariesHumansIndocyanine GreenReproducibility of ResultsSensitivity and SpecificityIndocyanine GreenCavitated proximal lesionsContrast mediumDiagnocamICGIndocyanin greenNear infrared transilluminationNIRProximal cariesTransillumination

Identifiers

PMID31682898
PMCPMC6885130
OpenAlexW2984015329

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.