ArticlePharmacology, biochemistry, and behavior2020
The activity-regulated cytoskeleton-associated protein, Arc/Arg3.1, influences mouse cocaine self-administration.
Article in Pharmacology, biochemistry, and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- CRISPR inhibition of activity-dependent Arc expression in the adult mouse brain has limited effects on plasticity in visual cortex and nucleus accumbens.bioRxiv : the preprint server for biology · 2026Article
- Dopamine D2S/D2L Receptor Regulation of Alcohol-Induced Reward and Signalling.Addiction biology · 2025Article
- Article
- Cocaine-context memories are transcriptionally encoded in nucleus accumbens Arc ensembles.Nature communications · 2025Article
- NeuropsychopharmARCology: Shaping Neuroplasticity through Arc/ Arg3.1 Modulation.Current neuropharmacology · 2025Review
- The activity-regulated cytoskeleton-associated protein (Arc) functions in a cell type- and sex-specific manner in the adult nucleus accumbens to regulate non-contingent cocaine behaviors.Genes, brain, and behavior · 2024Article
- The activity-regulated cytoskeleton-associated protein, Arc, functions in the nucleus accumbens shell to limit multiple triggers of cocaine-seeking behaviour.Addiction biology · 2023Article
- Cell-type specific transcriptional adaptations of nucleus accumbens interneurons to amphetamine.Molecular psychiatry · 2023Article
- Arc protein, a remnant of ancient retrovirus, forms virus-like particles, which are abundantly generated by neurons during epileptic seizures, and affects epileptic susceptibility in rodent models.Frontiers in neurology · 2023Review
- Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization.The EMBO journal · 2022Article
- Domain-selective BET inhibition attenuates transcriptional and behavioral responses to cocaine.Neuropharmacology · 2022Article
- Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway.BMC pharmacology & toxicology · 2022Article
- Jugular Vein Catheter Design and Cocaine Self-Administration Using Mice: A Comprehensive Method.Frontiers in behavioral neuroscience · 2022Article
- Effect of pharmacological manipulations on Arc function.Current research in pharmacology and drug discovery · 2021Review
- Effects of Ketamine on Learning and Memory in the Hippocampus of Rats through ERK, CREB, and Arc.Brain sciences · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The activity-regulated cytoskeleton-associated protein (Arc, also known as Arg3.1), an immediate early gene and synaptic regulator, is upregulated following a single cocaine exposure. However, there is not much known regarding Arc/Arg3.1's potential contribution to addiction-relevant behaviors. Despite known learning and memory deficits in contextual fear and water-maze reversal learning tasks, we find that mice lacking Arc/Arg3.1 perform conditioned place preference and operant conditioning involving positive reinforcers (food and cocaine) with little-to-no impairment. However, following normal saline-extinction, wild type (WT) mice show a classic inverted-U dose-response function, while Arc/Arg3.1 knockout (KO) mice fail to adjust their intake across multiple doses. Importantly, Arc/Arg3.1 KO and WT mice behave comparably on an increasing cost task (FR1-FR3; acquisition dose), providing evidence that both groups find cocaine reinforcing. Differences in individuals that drive variations in use patterns and particularly, drug intake levels, are critical as they influence the likelihood of developing dependence. Our data suggest that Arc/Arg3.1 may contribute to addiction as a regulator of drug-taking vulnerability under different drug availability conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.