Evidence map›Paper›PMID 31682851›Full record

ReviewGastroenterology2020

Causes of Socioeconomic Disparities in Colorectal Cancer and Intervention Framework and Strategies.

John M Carethers, Chyke A Doubeni

Open access · greenAbstract readReview
In one paragraph

Review in Gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 212 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
212citing papers in PubMed, 7 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

212 citing papers in PubMed, 7 syntheses or guidelines pooled it, 298 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Area-Level Determinants in Colorectal Cancer Spatial Clustering Studies: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Effects of culturally targeted message framing on colorectal cancer screening among African Americans.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2021
    Trial
  12. Article
  13. Exercise therapy in cancer prevention and treatment.Nature reviews. Clinical oncology · 2026
    Review
  14. Observational
  15. Review
  16. Article
  17. Article
  18. Article
  19. Monitoring of Colorectal Cancer Screening Adherence Among African American Patients of North Florida Community Health Centers.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026
    Article
  20. Article

152 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

John M CarethersDivision of Gastroenterology, Department of Internal Medicine, Department of Human Genetics and Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan. Electronic address: jcarethe@umich.edu.
Chyke A DoubeniCenter for Health Equity and Community Engagement Research, Mayo Clinic, Rochester, Minnesota; Department of Family Medicine, Mayo Clinic, Rochester, Minnesota.
Mayo Clinic · USUniversity of Michigan–Ann Arbor · US

Funding

Post-polypectomy Surveillance for Reducing Colon Cancer Incidence and MortalityR37CA222866 · NCI · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI GUPTA, SAMIR · 2018 to 2023
$3.3M
Effectiveness of screening for colorectal cancer in average risk adults: Colonoscopy vs. FITR01CA213645 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CORLEY, DOUGLAS ALLEN, DOUBENI, CHYKE ABADAMA · 2017 to 2021
$3.2M
(PQ3) Immune Modulation of DNA Mismatch Repair in Colorectal CancerR01CA206010 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARETHERS, JOHN M · 2016 to 2020
$1.8M
The Penn-StARR Program for Research in ResidencyR38HL143613 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KLEIN, PETER S · 2018 to 2021
$1.4M
NCI NIH HHS R01 CA206010NCI NIH HHS R01 CA213645NCI NIH HHS R37 CA222866NHLBI NIH HHS R38 HL143613
6 · The paper itself

Abstract

Colorectal cancer (CRC) disproportionately affects people from low socioeconomic backgrounds and some racial minorities. Disparities in CRC incidence and outcomes might result from differences in exposure to risk factors such as unhealthy diet and sedentary lifestyle; limited access to risk-reducing behaviors such as chemoprevention, screening, and follow-up of abnormal test results; or lack of access to high-quality treatment resources. These factors operate at the individual, provider, health system, community, and policy levels to perpetuate CRC disparities. However, CRC disparities can be eliminated. Addressing the complex factors that contribute to development and progression of CRC with multicomponent, adaptive interventions, at multiple levels of the care continuum, can reduce gaps in mortality. These might be addressed with a combination of health care and community-based interventions and policy changes that promote healthy behaviors and ensure access to high-quality and effective measures for CRC prevention, diagnosis, and treatment. Improving resources and coordinating efforts in communities where people of low socioeconomic status live and work would increase access to evidence-based interventions. Research is also needed to understand the role and potential mechanisms by which factors in diet, intestinal microbiome, and/or inflammation contribute to differences in colorectal carcinogenesis. Studies of large cohorts with diverse populations are needed to identify epidemiologic and molecular factors that contribute to CRC development in different populations.

Indexed as

Health Status DisparitiesSocioeconomic FactorsColorectal NeoplasmsEarly Detection of CancerHealthcare DisparitiesHealth Services AccessibilityHealthy LifestyleHumansIncidenceMass ScreeningMinority GroupsRisk FactorsCancer DisparityCancer Disparity InterventionsCancer EpidemiologyRacial Disparity

Identifiers

PMID31682851
PMCPMC6957741
OpenAlexW2986922148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.