ArticleNeuro-oncology2019
Symptom clusters in newly diagnosed glioma patients: which symptom clusters are independently associated with functioning and global health status?
Article in Neuro-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04717739 (Use of TTFields in Germany in Routine Clinical Care Study PROgram - Daily Activity, Sleep and Neurocognitive Functioning in Newly Diagnosed Glioblastoma Patients Study), which is not on this map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of TTFields in Germany in Routine Clinical Care Study PROgram - Daily Activity, Sleep and Neurocognitive Functioning in Newly Diagnosed Glioblastoma Patients Study
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Symptom management in adult brain tumours: A literature review.Nursing open · 2023Pooled it
- Interventions for the management of fatigue in adults with a primary brain tumour.The Cochrane database of systematic reviews · 2022Pooled it
- Bayesian adaptive randomized trial of blended cognitive behavioral therapy for severe fatigue in stable diffuse glioma.Neuro-oncology · 2026Trial
- Telehealth group Cognitive-Behavioral Therapy for Insomnia (CBT-I) in primary brain tumor: Primary outcomes from a single-arm phase II feasibility and proof-of-concept trial.Neuro-oncology · 2024Trial
- Symptom burden in young adult brain tumor survivors: Key intervention targets based on patient-reported outcome network analyses.Neuro-oncology practice · 2026Article
- Symptom network and latent profile analysis in patients after glioma surgery: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Bibliometric mapping of glioma classification research through main path, key route, and K-core analyses.Oncotarget · 2026Review
- Malnutrition-related symptom clusters and quality of life in nasopharyngeal carcinoma patients during radiotherapy: a network analysis.BMC cancer · 2026Article
- Multiscale network perspectives on glioma: from tumour biology to symptoms, survival and treatment.Nature reviews. Neurology · 2026Review
- Palliative care interventions and outcome in patients with glioblastoma - a retrospective, single-center study.BMC palliative care · 2026Article
- Identification of distinct symptom profiles in primary brain tumor patients: a prospective longitudinal study.BMC neurology · 2025Article
- Construction and validation of a risk prediction model for symptom cluster distress in brain tumor patients: a cross-sectional study.BMC cancer · 2025Article
- Enhancing cardiorespiratory fitness and quality of life in high-grade glioma through an intensive exercise intervention during chemotherapy: Proof of concept.Neuro-oncology · 2025Article
- Instruments for measuring fatigue in patients with brain tumours: protocol for a COSMIN--based systematic review.BMJ open · 2025Article
- Perioperative symptom cluster characteristics and supportive care needs of sellar tumor patients: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Observational
- Symptom and functional networks of patients with cancer in different latent risk subgroups based on patient-reported outcomes.BMC cancer · 2025Article
- Health-related quality of life in 62 patients with diffuse low-grade glioma during a non-therapeutic and progression-free phase: a cross-sectional study.Journal of neuro-oncology · 2025Article
- Baseline factors relating to depressive symptoms at one year postoperative in patients with diffuse glioma.Neuro-oncology practice · 2025Article
- Network Analysis of Multidimensional Symptoms and Inflammatory Biomarkers in Chinese Patients with Glioma.Journal of inflammation research · 2025Article
- Article
Corrections and comments
- Commented on by
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSymptom management in glioma patients remains challenging, as patients suffer from various concurrently occurring symptoms. This study aimed to identify symptom clusters and examine the association between these symptom clusters and patients' functioning.
methodsData of the CODAGLIO project was used, including individual patient data from previously published international randomized controlled trials (RCTs) in glioma patients. Symptom prevalence and level of functioning were assessed with European Organisation for Research and Treatment of Cancer (EORTC) quality of life QLQ-C30 and QLQ-BN20 self-report questionnaires. Associations between symptoms were examined with Spearman correlation coefficients and partial correlation networks. Hierarchical cluster analyses were performed to identify symptom clusters. Multivariable regression analyses were performed to determine independent associations between the symptom clusters and functioning, adjusted for possible confounders.
resultsIncluded in the analysis were 4307 newly diagnosed glioma patients from 11 RCTs who completed the EORTC questionnaires before randomization. Many patients (44%) suffered from 5-10 symptoms simultaneously. Four symptom clusters were identified: a motor cluster, a fatigue cluster, a pain cluster, and a gastrointestinal/seizures/bladder control cluster. Having symptoms in the motor cluster was associated with decreased (≥10 points difference) physical, role, and social functioning (betas ranged from -11.3 to -15.9, all P < 0.001), independent of other factors. Similarly, having symptoms in the fatigue cluster was found to negatively influence role functioning (beta of -12.3, P < 0.001), independent of other factors.
conclusionsTwo symptom clusters, the fatigue and motor cluster, were frequently affected in glioma patients and were found to independently have a negative association with certain aspects of patients' functioning as measured with a self-report questionnaire.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.