ArticlePloS one2019
Molecular evolution of cytochrome C oxidase-I protein of insects living in Saudi Arabia.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Emerging Risk of Flea-BorneInsects · 2025Article
- Molecular insights intoFrontiers in insect science · 2025Article
- Integrating wing morphometrics and mitochondrial DNA analysis to assess the filaria vector Mansonia uniformis (Diptera: Culicidae) populations in Thailand.Parasitology research · 2024Article
- Article
- Structure and molecular evolution of the barcode fragment of cytochrome oxidase I (COI) inEcology and evolution · 2022Article
- Molecular characterization and phylogenetic relationships amongSaudi journal of biological sciences · 2022Article
- Drivers for mutation in amino acid sequences of two mitochondrial proteins (Cytb and COI) in Phytoseiidae mites (Acari: Mesostigmata).Experimental & applied acarology · 2022Article
- Brain Size, Metabolism, and Social Evolution.Frontiers in physiology · 2021Article
- Advantages of an easy-to-use DNA extraction method for minimal-destructive analysis of collection specimens.PloS one · 2020Article
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Authors and funding
16 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study underpins barcode characterization of insect species collected from Saudi Arabia and explored functional constraints during evolution at the DNA and protein levels to expect the possible mechanisms of protein evolution in insects. Codon structure designated AT-biased insect barcode of the cytochrome C oxidase I (COI). In addition, the predicted 3D structure of COI protein indicated tyrosine in close proximity with the heme ligand, depicted substitution to phenylalanine in two Hymenopteran species. This change resulted in the loss of chemical bonding with the heme ligand. The estimated nucleotide substitution matrices in insect COI barcode generally showed a higher probability of transversion compared with the transition. Computations of codon-by-codon nonsynonymous substitutions in Hymenopteran and Hemipteran species indicated that almost half of the codons are under positive evolution. Nevertheless, codons of COI barcode of Coleoptera, Lepidoptera and Diptera are mostly under purifying selection. The results reinforce that codons in helices 2, 5 and 6 and those in loops 2-3 and 5-6 are mostly conserved and approach strong purifying selection. The overall results argue the possible evolutionary position of Hymenopteran species among those of other insects.
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