Trial reportDepression and anxiety2019
Comorbid anxiety in late-life depression: Relationship with remission and suicidal ideation on venlafaxine treatment.
Trial report in Depression and anxiety, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Moderators of treatment response in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Psychological symptom clusters in pregnant women: a scoping review.BMC psychology · 2026Article
- Prevalence, role impairment, and mental health service utilization of depressive disorders among community-dwelling older adults in China.Frontiers in psychiatry · 2026Article
- Psychotherapeutic treatments for depression in older adults.The Cochrane database of systematic reviews · 2024Article
- Personalized venlafaxine dose prediction using artificial intelligence technology: a retrospective analysis based on real-world data.International journal of clinical pharmacy · 2024Article
- Developing a machine learning model for predicting venlafaxine active moiety concentration: a retrospective study using real-world evidence.International journal of clinical pharmacy · 2024Article
- Cytokine profile in first-episode drug-naïve major depressive disorder patients with or without anxiety.BMC psychiatry · 2024Article
- Loneliness, Psychological Well-being, Depression, and Social Participation in the Older Persons: Rural and Urban Differences.Current aging science · 2024Article
- Article
- Gender differences in the association between anxiety symptoms and thyroid hormones in young patients with first-episode and drug naïve major depressive disorder.Frontiers in psychiatry · 2023Article
- Self-compassion predicted joint trajectories of depression and anxiety symptoms during the COVID-19 pandemic: A five-wave longitudinal study on Chinese college students.Journal of affective disorders · 2022Article
- The network of psychosocial health in middle-aged and older adults during the first COVID-19 lockdown.Social psychiatry and psychiatric epidemiology · 2022Article
- The associations among the stress symptoms, depressive symptoms, anxiety symptoms and insomnia symptoms in depressed patients after the first COVID-19 outbreak was initially controlled in China: A prospective cohort study.Journal of affective disorders · 2022Article
- A fast online questionnaire for screening mental illness symptoms during the COVID-19 pandemic.Translational psychiatry · 2022Article
- Effects of insomnia and levels of depression and anxiety symptoms on quality of life in people with epilepsy.BMC psychiatry · 2022Article
- Multiscale neural signatures of major depressive, anxiety, and stress-related disorders.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The efficacy of a transdiagnostic group cognitive behavioral intervention for Chinese elderly with emotional disorders: A one-year follow-up randomized clinical trial.Frontiers in psychiatry · 2022Article
- Trait Anxiety Mediates Impulsivity and Suicidal Ideation in Depression During COVID-19 Pandemic.Frontiers in psychiatry · 2022Article
- The Effects of Repetitive Transcranial Magnetic Stimulation on Anxiety in Patients With Moderate to Severe Traumatic Brain Injury: AFrontiers in neurology · 2020Article
- Regional White Matter Integrity Predicts Treatment Response to Escitalopram and Memantine in Geriatric Depression: A Pilot Study.Frontiers in psychiatry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveThe purpose of this study was to examine the influence of comorbid anxiety symptoms on antidepressant treatment remission in older adults with major depressive disorder (MDD).
methodIn this multisite clinical trial, 468 older adults aged 60 years or older with MDD received open-label protocolized treatment with venlafaxine extended release (ER) titrated to a maximum of 300 mg daily. At baseline, anxiety was assessed with the Anxiety Sensitivity Index, the Brief Symptom Inventory (BSI) anxiety subscale, and the Penn State Worry Questionnaire. To measure treatment response, depressive symptoms and suicidality were assessed every 1-2 weeks with the Montgomery-Asberg Depression Rating Scale and the 19-item Scale for Suicide Ideation; anxiety was assessed with the BSI. Logistic regression and survival analysis were used to evaluate whether anxiety symptoms predicted depression remission. We also examined the relationships between anxiety scores and suicidality at baseline.
resultsBaseline anxiety symptoms did not predict remission or time to remission of depressive symptoms. Depressive, worry, and panic symptoms decreased in parallel in patients with high anxiety. Anxiety symptoms were associated with the severity of depression and with suicidality.
conclusionIn older adults with MDD, comorbid anxiety symptoms are associated with symptom severity but do not affect antidepressant remission or time to remission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.