Evidence map›Paper›PMID 31682226›Full record

ArticleeLife2019

Chromosome territory formation attenuates the translocation potential of cells.

Leah F Rosin, Olivia Crocker, Randi L Isenhart, Son C Nguyen, Zhuxuan Xu, Eric F Joyce

Abstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
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  14. Spatial-Temporal Genome Regulation in Stress-Response and Cell-Fate Change.International journal of molecular sciences · 2023
    Review
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Leah F RosinDepartment of Genetics, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0002-2489-4016
Olivia CrockerDepartment of Genetics, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Randi L IsenhartDepartment of Genetics, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Son C NguyenDepartment of Genetics, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Zhuxuan XuDepartment of Genetics, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Eric F JoyceDepartment of Genetics, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0002-0418-2804

Funding

Regulation of chromatin folding in space and timeR35GM128903 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Eric F. Joyce · 2018 to 2026
$4.2M
NIGMS NIH HHS R35 GM128903NIGMS NIH HHS R35GM128903Pittsburgh Foundation KA2017-91787
6 · The paper itself

Abstract

The formation and spatial arrangement of chromosome territories (CTs) in interphase has been posited to influence the outcome and frequency of genomic translocations. This is supported by correlations between the frequency of inter-chromosomal contacts and translocation events in myriad systems. However, it remains unclear if CT formation itself influences the translocation potential of cells. We address this question in

Indexed as

InterphaseTranslocation, GeneticAdenosine TriphosphatasesAnimalsCell LineChromosomesCytogeneticsDNA-Binding ProteinsDrosophilaMultiprotein ComplexesAdenosine Triphosphatasescondensin complexesDNA-Binding ProteinsMultiprotein Complexescell biologychromosomeschromosome territoryCondensin IID. melanogasterFISHgene expressiongenome integrityoligopaintstranslocation

Identifiers

PMID31682226
PMCPMC6855801

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.