ArticleeLife2019
Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjærg syndrome.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- XLA-MTS: a distinct clinical genetic entity characterized by immunodeficiency and neurodevelopmental delay.Orphanet journal of rare diseases · 2026Pooled it
- Modelling mitochondrial diseases in neuronsJournal of neuromuscular diseases · 2025Pooled it
- Combining Fret and Super-Resolution Microscopy Reveals Kinase Activation and Mitochondrial Activity at the Nanoscale.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Hypoxia-responsive interaction between P-TEFb, BHLHE40, and Tim8-Tim13 regulates hypoxic gene transcription.Science advances · 2026Article
- The integrated stress response suppresses PINK1-dependent mitophagy by preserving mitochondrial import efficiency.Nature communications · 2026Article
- From the cytosol to the inner membrane: biogenesis of the mitochondrial carrier family.Protein science : a publication of the Protein Society · 2026Review
- Mitochondrial Microproteins: Emerging Regulators in Neurodevelopment and Neurodegeneration.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- TIMM8B promotes oxidative phosphorylation and glycolysis by inhibiting the mtROS/ASK1/JNK signaling pathway in ovarian cancer.Biology direct · 2025Article
- The oncogenic role of TIMM8A in cancer and the mechanistic insights into the function in breast cancer cells.Scientific reports · 2025Article
- CHCHD2 rescues the mitochondrial dysfunction in iPSC-derived neurons from patient with Mohr-Tranebjaerg syndrome.Cell death & disease · 2025Article
- Article
- Revealing mitochondrial architecture and functions with single molecule localization microscopy.Biology of the cell · 2025Review
- Reactive oxygen species control protein degradation at the mitochondrial import gate.Molecular cell · 2024Article
- CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex.The Journal of cell biology · 2024Article
- Article
- Unique Interactions of the Small Translocases of the Mitochondrial Inner Membrane (Tims) inInternational journal of molecular sciences · 2024Article
- Mitochondrial microproteins: critical regulators of protein import, energy production, stress response pathways, and programmed cell death.American journal of physiology. Cell physiology · 2023Review
- Human Tim8a, Tim8b and Tim13 are auxiliary assembly factors of mature Complex IV.EMBO reports · 2023Article
- Mitochondrial biology and dysfunction in secondary mitochondrial disease.Open biology · 2022Review
- Sideroflexin 4 is a complex I assembly factor that interacts with the MCIA complex and is required for the assembly of the ND2 module.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 3 institutions in 1 country.
Yilin KangDepartment of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Australia.
Alexander J AndersonDepartment of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Australia.
Thomas Daniel JacksonDepartment of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Australia.
Catherine S PalmerDepartment of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Australia.ORCID http://orcid.org/0000-0002-5124-2400
David P De SouzaMetabolomics Australia, The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia.
Kenji M FujiharaDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Australia.
Tegan StaitMurdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.
Ann E FrazierMurdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.
Nicholas J ClemonsDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Australia.ORCID http://orcid.org/0000-0001-9283-9978
Deidreia TullMetabolomics Australia, The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia.
David R ThorburnMurdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.
Malcolm J McConvilleMetabolomics Australia, The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Australia.
Michael T RyanDepartment of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
David A StroudDepartment of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Australia.
Diana StojanovskiDepartment of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Australia.ORCID https://orcid.org/0000-0002-0199-3222
The University of Melbourne · AURoyal Children's Hospital · AUAustralian Regenerative Medicine Institute · AU
Funding
Australian Research Council DP170101249Mito Foundation Research FellowshipNHMRC Fellowship 1022896NHMRC Fellowship 1059530NHMRC Fellowship 1140851NHMRC Project Grant 1107094NHMRC Project Grant 1125390NHMRC Project Grant 1140906Victorian Cancer Agency MCRF16002
Abstract
Human Tim8a and Tim8b are members of an intermembrane space chaperone network, known as the small TIM family. Mutations in
Indexed as
Protein MultimerizationApoptosisApoptosis Regulatory ProteinsCell LineCopper Transport ProteinsDeaf-Blind DisordersDystoniaElectron Transport Complex IVHumansIntellectual DisabilityMembrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsNeuronsOptic AtrophyOxidative StressProtein Interaction MapsApoptosis Regulatory ProteinsCopper Transport ProteinsCOX17 protein, humanElectron Transport Complex IVMembrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsTIMM8A protein, humancell biologychaperonesComplex IVhumanmitochondriamitochondrial diseaseprotein trafficking
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.