ArticleeLife2019
Protein polyglutamylation catalyzed by the bacterial calmodulin-dependent pseudokinase SidJ.
Abstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed.
- GeoEPred: A multimodal structure-aware geometric deep learning framework for Gram-negative bacterial secreted effector prediction with sequence semantics.PLoS computational biology · 2026Article
- Ubiquitination and autophagy in host-pathogen interactions: from immune surveillance to therapeutic targeting.Nature reviews. Immunology · 2026Review
- Bacterial ubiquitin ligase engineered for small molecule and protein target identification.The EMBO journal · 2026Article
- Structural and evolutionary insights into understudied bacterial serine-threonine pseudokinase families.Biochemical Society transactions · 2025Review
- Post-translational weapons of microbial warfare: how bacterial effectors hijack host cell death and xenophagy.Cell communication and signaling : CCS · 2025Review
- Regulation of host immunity by a novel Legionella pneumophila E3 ubiquitin ligase.PLoS pathogens · 2025Article
- Secreted retropepsin-like enzymes are essential for stress tolerance and biofilm formation inmBio · 2025Article
- Insights into mechanisms of ubiquitin ADP-ribosylation reversal.Biochemical Society transactions · 2024Review
- Review
- A random mutagenesis screen enriched for missense mutations in bacterial effector proteins.G3 (Bethesda, Md.) · 2024Article
- Bacterial ubiquitin ligases hijack the host deubiquitinase OTUB1 to inhibit MTORC1 signaling and promote autophagy.Autophagy · 2024Article
- Sde proteins coordinate ubiquitin utilization and phosphoribosylation to establish and maintain the Legionella replication vacuole.Nature communications · 2024Article
- Multi-tiered actions ofeLife · 2024Article
- Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain.Nature communications · 2024Article
- Legionella pneumophila-mediated host posttranslational modifications.Journal of molecular cell biology · 2023Review
- Sde Proteins Coordinate Ubiquitin Utilization and Phosphoribosylation to Promote Establishment and Maintenance of theResearch square · 2023Article
- Ubiquitin-targeted bacterial effectors: rule breakers of the ubiquitin system.The EMBO journal · 2023Review
- Emerging functions of pseudoenzymes.The Biochemical journal · 2023Review
- Mechanism and Modulation of SidE Family Proteins in the Pathogenesis ofPathogens (Basel, Switzerland) · 2023Review
- Redefining pseudokinases: A look at the untapped enzymatic potential of pseudokinases.IUBMB life · 2023Review
Corrections and comments
- Commented on by
Authors and funding
11 authors.
Alan Sulpizio *Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States.ORCID 0000-0001-7112-8579
Marena E Minelli *Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States.ORCID 0000-0002-3257-4047
Min Wan *Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States.ORCID 0000-0001-6836-8491
Paul D BurrowesWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States.
Xiaochun WuWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States.
Ethan J SanfordWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States.
Jung-Ho ShinWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States.
Byron C WilliamsDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, United States.
Michael L GoldbergDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, United States.ORCID 0000-0003-0200-0277
Marcus B SmolkaWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States.
Yuxin MaoWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States.ORCID 0000-0002-5064-1397
Funding
Life Science and Biomedical technology Research center at NSLS-II LSBRP41GM111244 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI MCSWEENEY, SEAN · 2014 to 2018
$16.4MTRAINING IN MOLECULAR PHYSICS OF BIOLOGICAL SYSTEMST32GM008267 · NIGMS · CORNELL UNIVERSITY ITHACA · PI WANG, MICHELLE D. · 1988 to 2021
$9.6MCellular Responses to DNA Replication StressR01GM097272 · NIGMS · CORNELL UNIVERSITY · PI SMOLKA, MARCUS · 2011 to 2020
$2.7MTHE MECHANISM OF A NOVEL FAMILY OF BACTERIAL UBIQUITIN E3 LIGASES IMPORTANT FOR PHAGOSOME REMODELINGR01GM116964 · NIGMS · CORNELL UNIVERSITY · PI MAO, YUXIN · 2016 to 2019
$1.3MNational Institute for Health Research 5R01GM116964NIGMS NIH HHS P41 GM111244NIGMS NIH HHS R01 GM097272NIGMS NIH HHS R01 GM116964NIGMS NIH HHS Ruth L Kirschstein National Research Service Award (6T32GM008267)NIGMS NIH HHS T32 GM008267
Abstract
Pseudokinases are considered to be the inactive counterparts of conventional protein kinases and comprise approximately 10% of the human and mouse kinomes. Here, we report the crystal structure of the
Indexed as
Protein Processing, Post-TranslationalBacterial ProteinsCalmodulinCrystallography, X-RayGlutamatesHumansLegionella pneumophilaMass SpectrometryMembrane ProteinsProtein ConformationVirulence FactorsBacterial ProteinsCalmodulinGlutamatesMembrane ProteinsSdeA protein, Legionella pneumophilaSidJ protein, Legionella pneumophilaVirulence Factorsbiochemistrychemical biologyglutamylationLegionella pneumophilamolecular biophysicsphosphoribosyl ubiquitinationSdeASidJstructural biologyubiquitin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.