Evidence map›Paper›PMID 31682199›Full record

ArticleEmerging microbes & infections2019

Antigenic variations of recent street rabies virus.

Wenbo Wang, Jian Ma, Jianhui Nie, Jia Li, Shouchun Cao, Lan Wang, Chuanfei Yu, Weijin Huang, Yuhua Li, Yongxin Yu and 6 more

Open access · goldAbstract read
In one paragraph

Article in Emerging microbes & infections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  6. Pseudotyped Viruses for Lyssavirus.Advances in experimental medicine and biology · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Neglected challenges in the control of animal rabies in China.One health (Amsterdam, Netherlands) · 2021
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Wenbo WangCollege of Life Science, Jilin University, Changchun, People's Republic of China.
Jian MaDivision of HIV/AIDS and Sex-Transmitted Virus Vaccines, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Jianhui NieDivision of HIV/AIDS and Sex-Transmitted Virus Vaccines, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Jia LiDivision of Arboviral Vaccine, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Shouchun CaoDivision of Arboviral Vaccine, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Lan WangDivision of Monoclonal Antibody Products, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Chuanfei YuDivision of Monoclonal Antibody Products, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Weijin HuangDivision of HIV/AIDS and Sex-Transmitted Virus Vaccines, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Yuhua LiDivision of Arboviral Vaccine, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Yongxin YuDivision of Arboviral Vaccine, National Institutes for Food and Drug Control (NIFDC), Beijing, People's Republic of China.
Mifang LiangKey Laboratory for Medical Virology, NHFPC, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, People's Republic of China.
Brett ZirkleDepartment of Molecular and Computational Biology/Chemistry Department/Norris Cancer Center, University of Southern California, Los Angeles, CA, USA.
Xiaojiang S ChenDepartment of Molecular and Computational Biology/Chemistry Department/Norris Cancer Center, University of Southern California, Los Angeles, CA, USA.
Xuguang LiCentre for Biologics Evaluation, Biologics and Genetic Therapies Directorate, Health Canada, Canada.
Wei KongCollege of Life Science, Jilin University, Changchun, People's Republic of China.
Youchun WangCollege of Life Science, Jilin University, Changchun, People's Republic of China.
National Institutes for Food and Drug Control · CNJilin University · CNUSC Norris Comprehensive Cancer Center · USCenter for Biologics Evaluation and Research · USChinese Center For Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genetic and/or antigenic differences between street rabies virus (RABV) and vaccine strains could potentially affect effectiveness of rabies vaccines. As such, it is important to continue monitoring the glycoprotein (G) of the street isolates. All RABVG sequences in public database were retrieved and analysed. Using a pseudovirus system, we investigated 99 naturally occurring mutants for their reactivities to well-characterized neutralizing monoclonal antibodies (mAbs) and vaccine-induced antisera. A divergence in G sequences was found between vaccine strains and recent street isolates, with mutants demonstrating resistance to neutralizing mAbs and vaccine-induced antibodies. Moreover, antigenic variants were observed in a wide range of animal hosts and geographic locations, with most of them emerging since 2010. As the number of antigenic variants has increased in recent years, close monitoring on street isolates should be strengthened.

Indexed as

Antigenic VariationAnimalsAntibodies, NeutralizingAntibodies, ViralFemaleGuinea PigsHumansNeutralization TestsRabiesRabies VaccinesRabies virusViral Envelope ProteinsAntibodies, NeutralizingAntibodies, ViralRabies VaccinesViral Envelope Proteinsglycoproteinmonoclonal antibodyneutralizationRabies virusvaccine

Identifiers

PMID31682199
PMCPMC6844422
OpenAlexW2986507273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.