Evidence map›Paper›PMID 31682042›Full record

ReviewExperimental dermatology2020

Stress test of the skin: The cutaneous permeability barrier treadmill.

Matthias Schmuth, Kenneth R Feingold, Peter M Elias

Open access · bronzeAbstract readReview
In one paragraph

Review in Experimental dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Adult skin acute stress responses to short-term environmental and internal aggression from exposome factors.Journal of the European Academy of Dermatology and Venereology : JEADV · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Matthias SchmuthDermatology, Medical University Innsbruck, Innsbruck, Austria.ORCID 0000-0002-4064-1334
Kenneth R FeingoldMetabolism Section, Department of Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA, USA.
Peter M EliasDermatology, Veterans Affair Medical Center, University of California-San Francisco, San Francisco, CA, USA.
San Francisco VA Medical Center · USInnsbruck Medical University · AT

Funding

Pathogenesis and Therapy of Ichthyosis in Disorders of Lipid MetabolismR01AR061106 · NIAMS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MAURO, THEODORA M · 2012 to 2022
$3.3M
Austrian Science Fund I 4229NIAMS NIH HHS R01 AR061106Walter Schaar Foundation
6 · The paper itself

Abstract

Studying skin barrier function is central to our understanding of many skin disorders. The past decade has seen a surge of skin barrier related investigative work. Genetic, biochemical and cell biology experiments have added much evidence to the importance of the barrier in disease pathogenesis of a variety of disorders including ichthyosis, atopic dermatitis and psoriasis. However, functional assays prove ever more important to demonstrate relevance of any of these findings. A paper published by Monash and Blank 60 years ago describes a stress test of the skin barrier, measuring skin barrier recovery, a functional test of tremendous implications. This seminal paper has not been cited for almost 15 years, time to acknowledge its critical importance and to review the relevance of this method today.

Indexed as

Skin Physiological PhenomenaStress, PhysiologicalDiagnostic Techniques and ProceduresEpidermisHumansPermeabilityRecovery of FunctionWater Loss, Insensibleepidermismetabolismpermeabilitysignallingskinstratum corneum

Identifiers

PMID31682042
PMCPMC6989371
OpenAlexW2984593288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.