Evidence map›Paper›PMID 31681857›Full record

ArticleWellcome open research2019

Expert voices and equal partnerships: establishing Controlled Human Infection Models (CHIMs) in Vietnam.

Evelyne Kestelyn, Chi Le Phuong, Jennifer Ilo Van Nuil, Hoai Tam Dong Thi, Nguyet Minh Nguyen, Trung Dinh The, Mary Chambers, Cameron P Simmons, Toan Nguyen Trong, Dung Nguyen The and 7 more

Abstract read
In one paragraph

Article in Wellcome open research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Evelyne KestelynOxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.ORCID https://orcid.org/0000-0002-5728-0918
Chi Le PhuongOxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.ORCID https://orcid.org/0000-0003-0312-292X
Jennifer Ilo Van NuilOxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.ORCID https://orcid.org/0000-0002-5167-5505
Hoai Tam Dong ThiOxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.
Nguyet Minh NguyenOxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.ORCID https://orcid.org/0000-0002-5960-7849
Trung Dinh TheOxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.
Mary ChambersOxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.ORCID https://orcid.org/0000-0003-0535-3895
Cameron P SimmonsOxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.
Toan Nguyen TrongPasteur Institute, Ho Chi MInh City, Vietnam.
Dung Nguyen TheDepartment of Infectious Diseases, School of Medicine, Vietnam National University, Ho Chi Minh City, Vietnam.
Le Truc PhuongNguyen Tri Phuong Hospital, Ho Chi Minh City, Vietnam.
Dung Do VanUniversity of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.ORCID https://orcid.org/0000-0001-6872-3481
Dung Duc AnhUniversity of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.
Vinh Chau Nguyen VanOxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.ORCID https://orcid.org/0000-0003-4668-1019
Stephen BakerOxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.
Bridget WillsOxford University Clinical Research Unit, University of Oxford, Ho Chi Minh City, Vietnam.ORCID https://orcid.org/0000-0001-9086-8804
OUCRU Controlled Human Infection Models workshop and focus group participants

Funding

Wellcome Trust
6 · The paper itself

Abstract

The number of controlled human infection models (CHIMs) conducted worldwide has increased considerably in recent years, although few have been conducted in low and middle-income countries (LMICs), where infectious diseases have the greatest burden. Recently Oxford University Clinical Research Unit (OUCRU) in Ho Chi Minh City (HCMC) started developing CHIM research proposals motivated by the need to develop a clearer and more grounded understanding of the issues surrounding the conduct of CHIMs in LMICs. To explore initial perceptions and barriers to conducting CHIMs in Vietnam, OUCRU researchers conducted a set of key stakeholder interviews early in 2018 and held a CHIM workshop in HCMC in March 2018. This paper summarizes the discussions from the workshop and outlines a way forward for conducting CHIMs in Vietnam.

Indexed as

CHIMControlled human infection modelHuman Challenge Studiesvaccineworkshop report

Identifiers

PMID31681857
PMCPMC6820821

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.