ArticleJournal of family medicine and primary care2019
Salivary antioxidant enzymes and lipid peroxidation product malondialdehyde and sialic acid levels among smokers and non-smokers with chronic periodontitis-A clinico-biochemical study.
Article in Journal of family medicine and primary care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- The assessment of glutathione, glutathione peroxidase, glutathione reductase, and oxidized glutathione in patients with periodontitis-A systematic review and meta-analysis.Clinical and experimental dental research · 2024Pooled it
- Evaluation of Salivary Biomarkers of Periodontal Disease Based on Smoking Status: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Salivary glutathione peroxidase-1 levels in periodontitis.World journal of methodology · 2026Article
- Oxidative stress and antioxidant pathways in the pathogenesis of periodontitis and peri-implantitis: mechanistic insights and therapeutic potentials.Frontiers in oral health · 2026Review
- Green Synthesis and Characterization of Silver and Gold Nanoparticles UsingOxidative medicine and cellular longevity · 2025Article
- Periodontal Health and Total Antioxidant Capacity for Jordanian Smokers at Dental Teaching Clinic.International journal of dentistry · 2025Article
- Therapeutic potential of farnesoid X receptor agonists for modulating inflammation and periodontal regeneration.Clinical oral investigations · 2024Article
- Determination of the Anti-Oxidative Stress Mechanism ofACS omega · 2023Article
- Lipid Peroxidation Levels in Saliva and Plasma of Patients Suffering from Periodontitis.Journal of clinical medicine · 2022Article
- Serum Inflammatory and Prooxidant Marker Levels in Different Periodontal Disease Stages.Healthcare (Basel, Switzerland) · 2021Article
- [Periostin inhibits hypoxia-induced oxidative stress and apoptosis in human periodontal ligament fibroblastsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Blood Oxidative Stress Modulates Alveolar Bone Loss in Chronically Stressed Rats.International journal of molecular sciences · 2020Article
- Evaluation of salivary biomarkers of periodontitis among smokers and nonsmokers: A novel study.Journal of family medicine and primary care · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPathogenesis of most of the inflammatory process are associated with reactive oxygen species (ROS), derived from various metabolic sources and which may lead to direct or indirect tissue damage due to oxidative stress, resulting in periodontal diseases. Usually antioxidant systems are capable of removing free radicals, thereby preventing tissue damage from free radical. ROS can result in tissue damage, involving lipid peroxidation. The aim of this study was to evaluate and compare the levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA), and sialic acid (SA) in periodontally healthy and chronic periodontitis among nonsmokers and smokers and to determine their value as diagnostic markers for chronic periodontitis. MATERIALS AND
methodsA total of 90 male patients aged 20--60 years were recruited and grouped as Group 1: 30 Healthy nonsmokers, who had never smoked. Group 2: 30 nonsmokers with chronic periodontitis. Group 3: 30 smokers with chronic periodontitis. Unstimulated saliva was collected for at least 5 min and clinical measurements; SOD, GPx, MDA and SA were assessed using a spectrophotometric method.
resultsData showed a significant correlation between salivary SOD, GPx, MDA, and SA in group 1, group 2, and group 3. SOD and GPx were found to be lower and MDA and SA levels were found to be higher among smokers with chronic periodontitis.
conclusionReduced levels of antioxidant enzymes SOD and GPx and elevated levels of lipid peroxidation product MDA as well as increased levels of SA could be used as diagnostic markers to measure oxidative stress in periodontal disease associated with risk factor such as smoking.
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Registered trials
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