Evidence map›Paper›PMID 31681640›Full record

ReviewJournal of family medicine and primary care2019

Calciphylaxis and its diagnosis: A review.

Deepak Baby, Meenakshi Upadhyay, M Derick Joseph, Swati Joshi Asopa, Basanta Kumar Choudhury, Jagadish Prasad Rajguru, Shivangi Gupta

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Journal of family medicine and primary care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04592640 (Effects of Human Amniotic-derived Mesenchymal Stem Cells), which is not on this map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04592640 early_phase1recruitingnot on this map

Effects of Human Amniotic-derived Mesenchymal Stem Cells (hAMSCs) on Calciphylaxis Patients: An Open-Label Single-Arm Study

TypeinterventionalSponsorThe First Affiliated Hospital with Nanjing Medical UniversityRan2018 to 2028Enrolled9ConditionsChronic Kidney Diseases, Calciphylaxis, Calcific Uremic Arteriolopathy, TreatmentArmsHuman amniotic-derived mesenchymal stem cells
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. A Case Report of Calciphylaxis.Journal of education & teaching in emergency medicine · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Chronic wounds.Nature reviews. Disease primers · 2022
    Review
  15. Article
  16. Retinal artery and vein occlusion in calciphylaxis.American journal of ophthalmology case reports · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Deepak BabyDepartment of Conservative Dentistry and Endodontics, P.S.M Dental College and Research Centre, Akkikavu, Thrissur, Kerala, India.
Meenakshi UpadhyayDepartment of Pediatric and Preventive Dentistry, Saraswati Dental College, Lucknow, Uttar Pradesh, India.
M Derick JosephDepartment of Conservative Dentistry and Endodontics, P.S.M Dental College and Research Centre, Akkikavu, Thrissur, Kerala, India.
Swati Joshi AsopaDepartment of Prosthodontics, Rajasthan Dental College and Hospital, Jaipur, Rajasthan, India.
Basanta Kumar ChoudhuryDepartment of Oral Medicine and Radiology, Institute of Dental Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.
Jagadish Prasad RajguruDepartment of Oral and Maxillofacial Pathology, Hi-Tech Dental College and Hospital, Bhubaneswar, Odisha, India.
Shivangi GuptaDepartment of Periodontics, Private Practitioner, Chandigarh, India.
Chandigarh University · INSaraswati Dental College and Hospital · INSiksha O Anusandhan University · INRajasthan Dental College and Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calciphylaxis also known as Calcific uremic arteriolopathy (CUA), is a rare fatal complication usually associated with end-stage renal disease (ESRD). It is characterized by skin ulceration and necrosis leading to significant pain. The disease calciphylaxis is pathological state resulting in accumulation of calcium content in medial wall of small blood vessels along with the fibrotic changes in intima. The aetiopathogenesis of this disease, small vessel vasculopathy, remains complicated, and unclear. It is believed that development of calciphylaxis depends on medial calcification, intimal fibrosis of arterioles and thrombotic occlusion. The disease is rare, life-threatening medical condition that occurs mostly in population with kidney disease or in patients on dialysis. Skin biopsy and radiographic features are helpful in the diagnosis of calciphylaxis, but negative results do not necessarily exclude the diagnosis. This article highlights steps undertaking in the diagnosis of calciphylaxis.

Indexed as

Calciphylaxiscalciumsmall blood vessels

Identifiers

PMID31681640
PMCPMC6820424
OpenAlexW2977934112

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.