Evidence map›Paper›PMID 31681604›Full record

ArticleFrontiers in oncology2019

MiR-199a Inhibits Tumor Growth and Attenuates Chemoresistance by Targeting K-RAS via AKT and ERK Signalings.

Wei Li, Lin Wang, Xiang-Bo Ji, Li-Hong Wang, Xin Ge, Wei-Tao Liu, Ling Chen, Zhong Zheng, Zhu-Mei Shi, Ling-Zhi Liu and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Wei LiDepartment of Pathology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Lin WangInstitute of Medical and Pharmaceutical Sciences, The Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.
Xiang-Bo JiInstitute of Medical and Pharmaceutical Sciences, The Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.
Li-Hong WangInstitute of Medical and Pharmaceutical Sciences, The Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.
Xin GeKey Laboratory of Human Functional Genomics of Jiangsu Province, Department of Pathology, Nanjing Medical University, Nanjing, China.
Wei-Tao LiuKey Laboratory of Human Functional Genomics of Jiangsu Province, Department of Pathology, Nanjing Medical University, Nanjing, China.
Ling ChenDepartment of Pathology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Zhong ZhengDepartment of Pathology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Zhu-Mei ShiKey Laboratory of Human Functional Genomics of Jiangsu Province, Department of Pathology, Nanjing Medical University, Nanjing, China.
Ling-Zhi LiuDepartment of Pathology, Carver College of Medicine, The University of Iowa, Iowa, IA, United States.
Marie C LinInstitute of Medical and Pharmaceutical Sciences, The Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.
Jie-Yu ChenDepartment of Pathology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Bing-Hua JiangInstitute of Medical and Pharmaceutical Sciences, The Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.
Nanjing Drum Tower Hospital · CNNanjing Medical University · CNZhengzhou University · CNUniversity of Iowa · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Brandi Janssen · 1990 to 2026
$40.5M
Mechanism of lung cancer resistance to tyrosine kinase inhibitor and radiation treatmentsR01CA232587 · NCI · UNIVERSITY OF IOWA · PI SIMONE, NICOLE L · 2018 to 2022
$2.9M
Molecular Mechanism of Arsenic CarcinogenesisR01ES020868 · NIEHS · UNIVERSITY OF IOWA · PI JIANG, BINGHUA · 2014 to 2018
$1.7M
NOX4 Mediates Oxidative Stress in Ovarian Tumor growth and treatment ResponseR01CA193511 · NCI · UNIVERSITY OF IOWA · PI HE, JUN · 2016 to 2020
$1.7M
Chromium in carcinogenesis and angiogenesisR01ES027901 · NIEHS · UNIVERSITY OF IOWA · PI HE, JUN · 2018 to 2022
$1.6M
New Mechanism of Arsenic CarcinogenesisK02ES029119 · NIEHS · UNIVERSITY OF IOWA · PI LIU, LING-ZHI · 2018 to 2022
$613k
NCI NIH HHS R01 CA193511NCI NIH HHS R01 CA232587NIEHS NIH HHS K02 ES029119NIEHS NIH HHS P30 ES005605NIEHS NIH HHS R01 ES020868NIEHS NIH HHS R01 ES027901
6 · The paper itself

Abstract

Glioma is the most malignant brain tumors in the world, the function and molecular mechanism of microRNA-199a (miR-199a) in glioma is not fully understood. Our research aims to investigate miR-199a/K-RAS axis in regulation of glioma tumor growth and chemoresistance. The function of miR-199a in glioma was investigated through

Indexed as

chemoresistancegliomaK-RASmiR-199atumorigenesis

Identifiers

PMID31681604
PMCPMC6803549
OpenAlexW2980807285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.