ArticleMolecular systems design & engineering2017
Design of SERS nanotags for multiplexed lateral flow immunoassays.
Article in Molecular systems design & engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
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Who cites it
11 citing papers in PubMed.
- Gold nanostructures/quantum dots for the enhanced efficiency of organic solar cells.Nanoscale advances · 2024Review
- Applications of Gold Nanoparticles in Plasmonic and Nanophotonic Biosensing.Advances in biochemical engineering/biotechnology · 2024Review
- Gold Nanoparticle Paper Immunoassays for Sensing the Presence ofACS omega · 2023Article
- Challenges and opportunities for SERS in the infrared: materials and methods.Nanoscale advances · 2023Review
- Design and synthesis of gold nanostars-based SERS nanotags for bioimaging applications.Nanotheranostics · 2022Review
- Raman Scattering-Based Biosensing: New Prospects and Opportunities.Biosensors · 2021Review
- Automatic and sensitive detection of West Nile virus non-structural protein 1 with a portable SERS-LFIA detector.Mikrochimica acta · 2021Article
- Metal Nanoparticles-Enhanced Biosensors: Synthesis, Design and Applications in Fluorescence Enhancement and Surface-enhanced Raman Scattering.Chemistry, an Asian journal · 2020Review
- Signal amplification and quantification on lateral flow assays by laser excitation of plasmonic nanomaterials.Theranostics · 2020Review
- Reporter Selection for Nanotags in Multiplexed Surface Enhanced Raman Spectroscopy Assays.ACS omega · 2018Article
- Dual dye-loaded Au@Ag coupled to a lateral flow immunoassay for the accurate and sensitive detection ofRSC advances · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Surface enhanced Raman spectroscopy (SERS) has been attractive for enhancing the sensitivity of lateral flow immunoassays (LFA). A format that has enabled specific detection of biomarkers is to use Raman reporter molecules linked to gold nanoparticles (NPs), which are conjugated to antibodies specific for the target of interest. Many factors such as the NP and Ab properties and the method of signal readout impact the sensitivity of a SERS based immunoassay. To understand how to optimize assay sensitivity, we studied SERS readouts of multiplexed sandwich immunoassays for the zika and dengue non-structural protein 1 (NS1) biomarkers as a test case. We investigated the effect of NP shape on the SERS enhancement of the reporter molecules 1,2-bis(4-pyridyl)ethylene (BPE) and 4-mercaptobenzoic acid (MBA). We also performed SERS imaging of test lines to map the spatial distribution of signal in test lines on the nitrocellulose. Finally, we used a modified least squares analysis to differentiate reporter contributions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.