Evidence map›Paper›PMID 31681319›Full record

ArticleFrontiers in immunology2019

Human Miscarriage Is Associated With Dysregulations in Peripheral Blood-Derived Myeloid Dendritic Cell Subsets.

Stefanie Ehrentraut, Karoline Sauss, Romy Neumeister, Lydia Luley, Anika Oettel, Franziska Fettke, Serban-Dan Costa, Stefanie Langwisch, Ana Claudia Zenclussen, Anne Schumacher

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

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  8. Overexpression of ERAP2N in Human Trophoblast Cells Promotes Cell Death.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Stefanie EhrentrautHealth Campus Immunology, Infectiology and Inflammation (GC-I3), Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Karoline SaussHealth Campus Immunology, Infectiology and Inflammation (GC-I3), Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Romy NeumeisterGynecologic Ambulance, Haldensleben, Germany.
Lydia LuleyHealth Campus Immunology, Infectiology and Inflammation (GC-I3), Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Anika OettelUniversity Women's Clinic, Otto-von-Guericke University, Magdeburg, Germany.
Franziska FettkeHealth Campus Immunology, Infectiology and Inflammation (GC-I3), Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Serban-Dan CostaUniversity Women's Clinic, Otto-von-Guericke University, Magdeburg, Germany.
Stefanie LangwischHealth Campus Immunology, Infectiology and Inflammation (GC-I3), Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Ana Claudia ZenclussenHealth Campus Immunology, Infectiology and Inflammation (GC-I3), Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Anne SchumacherHealth Campus Immunology, Infectiology and Inflammation (GC-I3), Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Otto-von-Guericke University Magdeburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DC) are critically involved in decisions related to the acceptance or rejection of the foreign fetal antigens by the maternal immune system. However, particularly for human peripheral blood DCs (PBDC), available literature is rather inconsistent and the factors regulating these cells are ill-defined. Here, we investigated the phenotype and functionality of different human PBDC subsets during normal and pathologic pregnancies and studied an involvement of human chorionic gonadotropin (hCG) in PBDC regulation. Peripheral blood samples were obtained from normal pregnant women in all three trimesters, from first trimester miscarriage patients and from healthy non-pregnant women. Samples were analyzed for plasma hCG levels, for regulatory T (Treg) cell numbers, for frequencies of total and mature plasmacytoid (PDC) and myeloid (MDC1 and MDC2) PBDC subsets and for their cytokine secretion.

Indexed as

Disease SusceptibilityAbortion, SpontaneousBiomarkersBiopsyCell CommunicationCell PlasticityCytokinesDendritic CellsFemaleHumansPregnancyT-LymphocytesT-Lymphocytes, RegulatoryBiomarkersCytokinesfetal tolerancehuman chorionic gonadotropinmyeloid dendritic cellsperipheral blood dendritic cellsplacenta factorsplasmacytoid dendritic cellspregnancyregulatory T cells

Identifiers

PMID31681319
PMCPMC6803452
OpenAlexW2980370953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.