Evidence map›Paper›PMID 31681317›Full record

ArticleFrontiers in immunology2019

Efficient Distribution of a Novel Zirconium-89 Labeled Anti-cd20 Antibody Following Subcutaneous and Intravenous Administration in Control and Experimental Autoimmune Encephalomyelitis-Variant Mice.

Mary-Anne Migotto, Karine Mardon, Jacqueline Orian, Gisbert Weckbecker, Rainer Kneuer, Rajiv Bhalla, David C Reutens

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05414487 (Exploring the Effects of B Cell Depletion With Ofatumumab on Immune Cells and Meningeal Lymphatic Drainage in Patients With Demyelinating Diseases - a Prospective Observational Study), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05414487 unknown statusnot on this mapstarted 2022, after this paper: background citation

Exploring the Effects of B Cell Depletion With Ofatumumab on Immune Cells and Meningeal Lymphatic Drainage in Patients With Demyelinating Diseases - a Prospective Observational Study

TypeobservationalSponsorTianjin Medical University General HospitalRan2022 to 2024Enrolled34ConditionsMultiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, Demyelinating Diseases of the Central Nervous SystemArmsOfatumumab
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Local immunosuppression in ofatumumab: a series of three cases with bacterial infections near the injection sites.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. New Long-Acting [Journal of medicinal chemistry · 2023
    Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Mary-Anne MigottoCentre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia.
Karine MardonCentre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia.
Jacqueline OrianDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Gisbert WeckbeckerNovartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Rainer KneuerNovartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
Rajiv BhallaCentre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia.
David C ReutensCentre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia.
University of Queensland · AUNovartis (Switzerland) · CHARC Centre of Excellence in Advanced Molecular Imaging · AULa Trobe University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Administration, IntravenousAnimalsAntibodies, MonoclonalAntigens, CD20Central Nervous SystemDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalFemaleHumansInjections, SubcutaneousMetabolic Clearance RateMice, Inbred C57BLMultiple SclerosisMyelin-Oligodendrocyte GlycoproteinPositron Emission Tomography Computed TomographyRadioisotopesAntibodies, MonoclonalAntigens, CD20Myelin-Oligodendrocyte GlycoproteinRadioisotopesZirconiumZirconium-89biodistributionexperimental autoimmune encephalomyelitisintravenousmonoclonal antibodyneuroimagingpositron emission tomography imagingradiolabelingsubcutaneous

Identifiers

PMID31681317
PMCPMC6813232
OpenAlexW2981297167

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.