ArticleFrontiers in immunology2019
Dietary Antigens Induce Germinal Center Responses in Peyer's Patches and Antigen-Specific IgA Production.
Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Germinal center responses at barrier organ sites.Current opinion in immunology · 2026Review
- Helminth Infection, Gut Microbiome Alterations, and Their Impact on Pulmonary Tuberculosis Susceptibility.Journal of tropical medicine · 2026Review
- Capsaicin attenuates high-fat diet-induced impairment of B-cell immunity.SAGE open medicine · 2026Article
- Effect of prenatal antibiotics on breast milk and neonatal IgA and microbiome: a case-control translational study protocol.Pediatric research · 2025Article
- Design of Mucosal Vaccines Against Swine Enteric Coronaviruses: From Antigen Delivery to Immune Activation.Transboundary and emerging diseases · 2025Review
- A mouse protozoan boosts antigen-specific mucosal IgA responses in a specific lipid metabolism- and signaling-dependent manner.Nature communications · 2024Article
- All roads lead to IgA: Mapping the many pathways of IgA induction in the gut.Immunological reviews · 2024Review
- B cell academy of the gut: an update on gut associated germinal centre B cell dynamics.Molecular and cellular pediatrics · 2024Review
- Food antigens suppress small intestinal tumorigenesis.Frontiers in immunology · 2024Article
- Programmed and environmental determinants driving neonatal mucosal immune development.Immunity · 2023Review
- From germ-free to wild: modulating microbiome complexity to understand mucosal immunology.Mucosal immunology · 2022Review
- Weaning differentially affects the maturation of piglet peripheral blood and jejunal Peyer's patches.Scientific reports · 2022Article
- IgA in human health and diseases: Potential regulator of commensal microbiota.Frontiers in immunology · 2022Review
- Cecal Patches Generate Abundant IgG2b-Bearing B Cells That Are Reactive to Commensal Microbiota.Journal of immunology research · 2022Article
- The Probiotic StrainFrontiers in microbiology · 2022Article
- Regulation of B Cell Responses in SLE by Three Classes of Interferons.International journal of molecular sciences · 2021Review
- Article
- Germinal Centre Shutdown.Frontiers in immunology · 2021Review
- Long Chain Polyunsaturated Fatty Acids Docosahexaenoic Acid and Arachidonic Acid Supplementation in the Suckling and the Post-weaning Diet Influences the Immune System Development of T Helper Type-2 Bias Brown Norway Rat Offspring.Frontiers in nutrition · 2021Article
- B cells and the microbiota: a missing connection in food allergy.Mucosal immunology · 2021Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The primary induction sites for intestinal IgA are the gut-associated lymphoid tissues (GALT), such as Peyer's patches (PPs) and isolated lymphoid follicles (ILFs). The commensal microbiota is known to contribute to IgA production in the gut; however, the role of dietary antigens in IgA production is poorly understood. To understand the effect of dietary antigens on IgA production, post-weaning mice were maintained on an elemental diet without any large immunogenic molecules. We found that dietary antigens contribute to IgA production in PPs through induction of follicular helper T cells and germinal center B cells. The role of dietary antigens in the PP responses was further confirmed by adding bovine serum albumin (BSA) into the elemental diet. Although dietary antigens are important for PP responses, they have fewer effects than the microbiota on the development and maturation of ILFs. Furthermore, we demonstrated that dietary antigens are essential for a normal antigen-specific IgA response to
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