Evidence map›Paper›PMID 31681306›Full record

ReviewFrontiers in immunology2019

Dendritic Cells as Sensors, Mediators, and Regulators of Ischemic Injury.

Helong Dai, Angus W Thomson, Natasha M Rogers

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 49 citations in OpenAlex.

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  14. Oxidized Low-Density Lipoprotein and Its Role in Immunometabolism.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Helong DaiDepartment of Urological Organ Transplantation, The Second Xiangya Hospital of Central South University, Changsha, China.
Angus W ThomsonDepartment of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Natasha M RogersDepartment of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Second Xiangya Hospital of Central South University · CNUniversity of Pittsburgh · USWestmead Institute for Medical Research · AU

Funding

Transplant Pathology and Tissue Imaging Core (Core B)U19AI131453 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEMETRIS, ANTHONY J · 2017 to 2022
$8.4M
Regulatory Dendritic Cell Therapy in Live Donor Renal Transplant RecipientsU01AI136779 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THOMSON, ANGUS W · 2018 to 2022
$4.3M
Regulation of Liver DC Function and Transplant ToleranceR01AI118777 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THOMSON, ANGUS W · 2017 to 2021
$2.3M
Streptococcus pneumoniae capsule inhibitorR21AI137799 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YOTHER, JANET L · 2018 to 2019
$408k
NIAID NIH HHS R01 AI118777NIAID NIH HHS R21 AI137799NIAID NIH HHS U01 AI136779NIAID NIH HHS U19 AI131453
6 · The paper itself

Abstract

Dendritic cells (DCs) are highly specialized, bone marrow (BM)-derived antigen-processing and -presenting cells crucial to the induction, integration and regulation of innate, and adaptive immunity. They are stimulated by damage-associated molecular patterns (DAMPS) via pattern recognition receptors to promote inflammation and initiate immune responses. In addition to residing within the parenchyma of all organs as part of the heterogeneous mononuclear phagocyte system, DCs are an abundant component of the inflammatory cell infiltrate that appears in response to ischemia reperfusion injury (IRI). They can play disparate roles in the pathogenesis of IRI since their selective depletion has been found to be protective, deleterious, or of no benefit in mouse models of IRI. In addition, administration of DC generated and manipulated

Indexed as

Disease SusceptibilityImmunityImmunomodulationAnimalsBiomarkersCell CommunicationCell PlasticityDendritic CellsHumansHypoxiaIschemiaIschemic PreconditioningOrgan SpecificityPhenotypeReperfusion InjuryBiomarkersdendritic cellsheartischemic injurykidneyliver

Identifiers

PMID31681306
PMCPMC6803430
OpenAlexW2978888771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.