Evidence map›Paper›PMID 31681305›Full record

ReviewFrontiers in immunology2019

Progress Toward a Gonococcal Vaccine: The Way Forward.

Michael W Russell, Ann E Jerse, Scott D Gray-Owen

Registry-linked trialAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07758972 (A First in Human Phase I Randomized and Controlled Trial to Test Safety and Immunogenicity of a Multivalent Vaccine Against Neisseria Gonorrhoeae), which is not on this map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07758972 phase1recruitingnot on this mapstarted 2026, after this paper: background citation

A First in Human Phase I Randomized and Controlled Trial to Test Safety and Immunogenicity of a Multivalent Vaccine Against Neisseria Gonorrhoeae

TypeinterventionalSponsorLimmaTech Biologics AGRan2026 to 2027Enrolled142ConditionsNeisseria GonorrheaArmsLTB-NG6, Sodium Chloride 0.9%
3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Genomic analysis ofMicrobiology spectrum · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Inhibition ofmBio · 2026
    Article
  9. Review
  10. Frontiers in microbiology · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Management and prevention of Neisseria meningitidis and Neisseria gonorrhoeae infections in the context of evolving antimicrobial resistance trends.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael W RussellDepartment of Microbiology and Immunology, University at Buffalo, Buffalo, NY, United States.
Ann E JerseDepartment of Microbiology and Immunology, F. Edward Herbert School of Medicine, Uniformed Services University, Bethesda, MD, United States.
Scott D Gray-OwenDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

Funding

The Gonorrhea Vaccine Cooperative Research CenterU19AI144180 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI CRISS, ALISON K · 2019 to 2023
$10.7M
Using gonococcal TonB-dependent transporters as vaccine antigensU19AI144182 · NIAID · GEORGIA STATE UNIVERSITY · PI SEIB, KATE LOUISE · 2019 to 2023
$9.3M
Gonococcal Vaccine Evaluation in a Humanized Mouse ModelR01AI103400 · NIAID · BOSTON MEDICAL CENTER · PI WETZLER, LEE MARK · 2013 to 2020
$5.2M
Experimental Gonococcal VaccineR44AI115877 · NIAID · THERAPYX, INC. · PI AUCI, DOMINICK, RUSSELL, MICHAEL W · 2017 to 2022
$4.6M
Therapy and Prophylaxis for Genital Tract InfectionR44AI104067 · NIAID · THERAPYX, INC. · PI AUCI, DOMINICK, RUSSELL, MICHAEL W · 2014 to 2022
$4.4M
Rational design of transferrin binding protein-based vaccines to combat gonorrheaR01AI125421 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI CORNELISSEN, CYNTHIA N, GRAY-OWEN, SCOTT D · 2017 to 2021
$3.1M
CIHR PJT-153177CIHR PJT-392076NIAID NIH HHS R01 AI103400NIAID NIH HHS R01 AI125421NIAID NIH HHS R44 AI104067NIAID NIH HHS R44 AI115877NIAID NIH HHS U19 AI144180NIAID NIH HHS U19 AI144182
6 · The paper itself

Abstract

The concept of immunizing against gonorrhea has received renewed interest because of the recent emergence of strains of

Indexed as

Adaptive ImmunityAnimalsAntigenic VariationAntigens, BacterialBacterial VaccinesDisease Models, AnimalGonorrheaHost-Pathogen InteractionsHumansImmunity, InnateImmunizationNeisseria gonorrhoeaeResearchVaccinationAntigens, BacterialBacterial VaccinesantibodiesantigenscytokinesimmunityNeisseria gonorrhoeaeT cellsvaccine

Identifiers

PMID31681305
PMCPMC6803597

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.