Evidence map›Paper›PMID 31681301›Full record

ArticleFrontiers in immunology2019

A Viral-Vectored Multi-Stage Malaria Vaccine Regimen With Protective and Transmission-Blocking Efficacies.

Yenni Yusuf, Tatsuya Yoshii, Mitsuhiro Iyori, Hiroaki Mizukami, Shinya Fukumoto, Daisuke S Yamamoto, Talha Bin Emran, Fitri Amelia, Ashekul Islam, Intan Syafira and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  9. A two-dose viral-vectoredFrontiers in immunology · 2024
    Article
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  11. Review
  12. Review
  13. Article
  14. Article
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  19. Review
  20. Liver-Directed AAV8 Booster Vaccine ExpressingFrontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Yenni YusufLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Kanazawa, Japan.
Tatsuya YoshiiLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Kanazawa, Japan.
Mitsuhiro IyoriLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Kanazawa, Japan.
Hiroaki MizukamiDivision of Genetics Therapeutics, Centre for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan.
Shinya FukumotoNational Research Centre for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.
Daisuke S YamamotoDivision of Medical Zoology, Department of Infection and Immunity, Jichi Medical University, Shimotsuke, Japan.
Talha Bin EmranLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Kanazawa, Japan.
Fitri AmeliaLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Kanazawa, Japan.
Ashekul IslamLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Kanazawa, Japan.
Intan SyafiraLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Kanazawa, Japan.
Shigeto YoshidaLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Kanazawa, Japan.
Kanazawa University · JPJichi Medical University · JPObihiro University of Agriculture and Veterinary Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria parasites undergo several stages in their complex lifecycle. To achieve reductions in both the individual disease burden and malaria transmission within communities, a multi-stage malaria vaccine with high effectiveness and durability is a more efficacious strategy compared with a single-stage vaccine. Here, we generated viral-vectored vaccines based on human adenovirus type 5 (AdHu5) and adeno-associated virus serotype 1 (AAV1) expressing a fusion protein of the pre-erythrocytic stage

Indexed as

Genetic EngineeringAdenoviruses, HumanAnimalsAntibodies, ProtozoanAntigens, ProtozoanChromobox Protein Homolog 5DependovirusDisease Models, AnimalGene ExpressionGene OrderGenetic VectorsHumansMalariaMalaria VaccinesMicePlasmodium bergheiAntibodies, ProtozoanAntigens, ProtozoanCBX5 protein, humanChromobox Protein Homolog 5Malaria VaccinesPfs25 protein, Plasmodium falciparumProtozoan Proteinsadeno-associated virushuman adenovirus serotype 5multi-stage malaria vaccinePfs25Plasmodium falciparum circumsporozoite proteintransmission-blocking

Identifiers

PMID31681301
PMCPMC6803381
OpenAlexW2969640204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.