Evidence map›Paper›PMID 31681278›Full record

ArticleFrontiers in immunology2019

Dynamic Imprinting of the Treg Cell-Specific Epigenetic Signature in Developing Thymic Regulatory T Cells.

Susanne Herppich, Aras Toker, Beate Pietzsch, Yohko Kitagawa, Naganari Ohkura, Takahisa Miyao, Stefan Floess, Shohei Hori, Shimon Sakaguchi, Jochen Huehn

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. International journal of molecular sciences · 2026
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  8. Article
  9. Acsbg1 regulates differentiation and inflammatory properties of CD4+ T cells.European journal of microbiology & immunology · 2025
    Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. CD24 is expressed on FoxP3American journal of translational research · 2022
    Article
  15. Review
  16. Regulatory T Cells-Related Genes Are under DNA Methylation Influence.International journal of molecular sciences · 2021
    Review
  17. Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Susanne HerppichDepartment Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Aras TokerDepartment Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Beate PietzschDepartment Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Yohko KitagawaLaboratory of Experimental Immunology, World Premier International Research Center Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Naganari OhkuraLaboratory of Experimental Immunology, World Premier International Research Center Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Takahisa MiyaoLaboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Stefan FloessDepartment Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Shohei HoriRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Shimon SakaguchiLaboratory of Experimental Immunology, World Premier International Research Center Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Jochen HuehnDepartment Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Helmholtz Centre for Infection Research · DEOsaka International University · JPOsaka University · JPRIKEN Center for Integrative Medical Sciences · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulatory T (Treg) cells mainly develop within the thymus and arise from CD25

Indexed as

DNA MethylationAnimalsForkhead Transcription FactorsGenetic LociGenomic ImprintingMiceMice, TransgenicThymocytesThymus GlandT-Lymphocytes, RegulatoryForkhead Transcription FactorsFoxp3 protein, mousedemethylationepigenetic signatureFoxp3IL-2thymusTreg cellTreg cell precursorsTSDR

Identifiers

PMID31681278
PMCPMC6797672
OpenAlexW2980023673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.