Evidence map›Paper›PMID 31681274›Full record

ArticleFrontiers in immunology2019

Targeting the Aryl Hydrocarbon Receptor With Indole-3-Aldehyde Protects From Vulvovaginal Candidiasis via the IL-22-IL-18 Cross-Talk.

Monica Borghi, Marilena Pariano, Valentina Solito, Matteo Puccetti, Marina M Bellet, Claudia Stincardini, Giorgia Renga, Carmine Vacca, Federica Sellitto, Paolo Mosci and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. The Gut-Vagina Axis.Microorganisms · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. The role of the AHR in host-pathogen interactions.Nature reviews. Immunology · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Monica BorghiDepartment of Experimental Medicine, University of Perugia, Perugia, Italy.
Marilena ParianoDepartment of Experimental Medicine, University of Perugia, Perugia, Italy.
Valentina SolitoDepartment of Experimental Medicine, University of Perugia, Perugia, Italy.
Matteo PuccettiDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Marina M BelletDepartment of Experimental Medicine, University of Perugia, Perugia, Italy.
Claudia StincardiniDepartment of Experimental Medicine, University of Perugia, Perugia, Italy.
Giorgia RengaDepartment of Experimental Medicine, University of Perugia, Perugia, Italy.
Carmine VaccaDepartment of Experimental Medicine, University of Perugia, Perugia, Italy.
Federica SellittoDepartment of Experimental Medicine, University of Perugia, Perugia, Italy.
Paolo MosciDepartment of Veterinary Medicine, University of Perugia, Perugia, Italy.
Stefano BrancorsiniDepartment of Experimental Medicine, University of Perugia, Perugia, Italy.
Luigina RomaniDepartment of Experimental Medicine, University of Perugia, Perugia, Italy.
Claudio CostantiniDepartment of Experimental Medicine, University of Perugia, Perugia, Italy.
University of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vulvovaginal candidiasis (VVC) is a common mucosal infection caused by

Indexed as

Candidiasis, VulvovaginalAnimalsBasic Helix-Loop-Helix ProteinsCandida albicansFemaleIndolesInflammasomesInterleukin-18Interleukin-22InterleukinsMiceMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinReceptors, Aryl HydrocarbonSignal TransductionTh17 CellsAhr protein, mouseBasic Helix-Loop-Helix Proteinsindole-3-carbaldehydeIndolesInflammasomesInterleukin-18Interleukin-22InterleukinsNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseReceptors, Aryl Hydrocarbon3-IAldAhRIL-18IL-22vulvovaginal candidiasis

Identifiers

PMID31681274
PMCPMC6798081
OpenAlexW2979758115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.