Evidence map›Paper›PMID 31680928›Full record

ArticleFrontiers in synaptic neuroscience2019

Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex.

Natalí Barros-Zulaica, John Rahmon, Giuseppe Chindemi, Rodrigo Perin, Henry Markram, Eilif Muller, Srikanth Ramaswamy

Abstract read
In one paragraph

Article in Frontiers in synaptic neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Reconstruction of the Hippocampus.Advances in experimental medicine and biology · 2022
    Article
  9. Article
  10. [Brain death criterion and organ donation: current neuroscientific perspective].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2020
    Review
  11. Article
  12. Review
  13. Cortical reliability amid noise and chaos.Nature communications · 2019
    Article
  14. Model-Based Inference of Synaptic Transmission.Frontiers in synaptic neuroscience · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Natalí Barros-ZulaicaBlue Brain Project, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland.
John RahmonBlue Brain Project, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland.
Giuseppe ChindemiBlue Brain Project, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland.
Rodrigo PerinLaboratory of Neural Microcircuitry, Brain Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Henry MarkramBlue Brain Project, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland.
Eilif MullerBlue Brain Project, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland.
Srikanth RamaswamyBlue Brain Project, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies based on the 'Quantal Model' for synaptic transmission suggest that neurotransmitter release is mediated by a single release site at individual synaptic contacts in the neocortex. However, recent studies seem to contradict this hypothesis and indicate that multi-vesicular release (MVR) could better explain the synaptic response variability observed

Indexed as

mathematical modelmulti vesicular releaseneocortexquantal analysisshort-term depressionsynaptic transmission

Identifiers

PMID31680928
PMCPMC6813366

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.