ArticleFrontiers in systems neuroscience2019
Entorhinal Layer II Calbindin-Expressing Neurons Originate Widespread Telencephalic and Intrinsic Projections.
Article in Frontiers in systems neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 40 citations in OpenAlex.
- An Update on the Model of Connectivity of the Hippocampal Formation (I): The Perforant Pathway to the Dentate Gyrus.Hippocampus · 2026Article
- Hippocampal architecture viewed through the eyes of methodological development.Anatomical science international · 2025Review
- Lateral Thinking: Exploring the Lateral Entorhinal Cortex Projections to the Hippocampus in the Rodent Brain.The Journal of comparative neurology · 2025Review
- Cell-type specific profiling of human entorhinal cortex at the onset of Alzheimer's disease neuropathology.bioRxiv : the preprint server for biology · 2025Article
- Bnip3 expression is strongly associated with reelin-positive entorhinal cortex layer II neurons.Brain structure & function · 2024Article
- Object-place-context learning impairment correlates with spatial learning impairment in aged Long-Evans rats.Hippocampus · 2024Article
- Progressive Excitability Changes in the Medial Entorhinal Cortex in the 3xTg Mouse Model of Alzheimer's Disease Pathology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Dissecting cell-type-specific pathways in medial entorhinal cortical-hippocampal network for episodic memory.Journal of neurochemistry · 2023Review
- Rat hippocampal CA1 region represents learning-related action and reward events with shorter latency than the lateral entorhinal cortex.Communications biology · 2023Article
- Progressive excitability changes in the medial entorhinal cortex in the 3xTg mouse model of Alzheimer's disease pathology.bioRxiv : the preprint server for biology · 2023Article
- Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β.Brain communications · 2023Article
- Article
- Microcircuits for spatial coding in the medial entorhinal cortex.Physiological reviews · 2022Review
- Article
- Precise Mapping of Otp Expressing Cells Across Different Pallial Regions Throughout Ontogenesis Using Otp-Specific Reporter Transgenic Mice.Frontiers in neural circuits · 2022Article
- Transcription factor 4 controls positioning of cortical projection neurons through regulation of cell adhesion.Molecular psychiatry · 2021Article
- Complementary roles of differential medial entorhinal cortex inputs to the hippocampus for the formation and integration of temporal and contextual memory (Systems Neuroscience).The European journal of neuroscience · 2021Review
- Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice.Science translational medicine · 2021Article
- Entorhinal cortical Island cells regulate temporal association learning with long trace period.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex.eLife · 2021Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study we provide the first systematic and quantitative hodological study of the calbindin-expressing (CB+) principal neurons in layer II of the entorhinal cortex and compared the respective projections of the lateral and medial subdivisions of the entorhinal cortex. Using elaborate quantitative retrograde tracing, complemented by anterograde tracing, we report that the layer II CB+ population comprises neurons with diverse, mainly excitatory projections. At least half of them originate local intrinsic and commissural projections which distribute mainly to layer I and II. We further show that long-range CB+ projections from the two entorhinal subdivisions differ substantially in that MEC projections mainly target field CA1 of the hippocampus, whereas LEC CB+ projections distribute much more widely to a substantial number of known forebrain targets. This connectional difference between the CB+ populations in LEC and MEC is reminiscent of the overall projection pattern of the two entorhinal subdivisions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.