Evidence map›Paper›PMID 31680852›Full record

ArticleFrontiers in molecular neuroscience2019

Snf2h Drives Chromatin Remodeling to Prime Upper Layer Cortical Neuron Development.

Matías Alvarez-Saavedra, Keqin Yan, Yves De Repentigny, Lukas E Hashem, Nidhi Chaudary, Shihab Sarwar, Doo Yang, Ilya Ioshikhes, Rashmi Kothary, Teruyoshi Hirayama and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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  9. Pathogenic variants inScience advances · 2021
    Article
  10. [A review on the genetic mechanism of chromatin remodeling in children with neurodevelopmental disorders].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Matías Alvarez-SaavedraRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Keqin YanRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Yves De RepentignyRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Lukas E HashemRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Nidhi ChaudaryRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Shihab SarwarRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Doo YangDepartments of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Ilya IoshikhesDepartments of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Rashmi KotharyRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Teruyoshi HirayamaKOKORO-Biology Group, Integrated Biology Laboratories, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan.
Takeshi YagiKOKORO-Biology Group, Integrated Biology Laboratories, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan.
David J PickettsRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
University of Ottawa · CAOttawa Hospital · CAOttawa Hospital Research InstituteOsaka University · JPTokushima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations in the homeostasis of either cortical progenitor pool, namely the apically located radial glial (RG) cells or the basal intermediate progenitors (IPCs) can severely impair cortical neuron production. Such changes are reflected by microcephaly and are often associated with cognitive defects. Genes encoding epigenetic regulators are a frequent cause of intellectual disability and many have been shown to regulate progenitor cell growth, including our inactivation of the

Indexed as

chromatin remodelingISWISmarca5Snf2htelencephalon development

Identifiers

PMID31680852
PMCPMC6811508
OpenAlexW2981209923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.