Evidence map›Paper›PMID 31680836›Full record

ArticleFrontiers in neuroscience2019

Alterations of the Gut Microbiota in Multiple System Atrophy Patients.

Linlin Wan, Xin Zhou, Chunrong Wang, Zhao Chen, Huirong Peng, Xuan Hou, Yun Peng, Puzhi Wang, Tianjiao Li, Hongyu Yuan and 8 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
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  7. Article
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  11. Colonization byFrontiers in immunology · 2025
    Article
  12. Article
  13. Probiotic potential ofFrontiers in microbiology · 2025
    Article
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  20. Potential ofFrontiers in microbiology · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Linlin WanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xin ZhouDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Chunrong WangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Zhao ChenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Huirong PengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xuan HouDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Yun PengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Puzhi WangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Tianjiao LiDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Hongyu YuanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Yuting ShiDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Xiaocan HouDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Keqin XuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Yue XieDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Lang HeDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Kun XiaLaboratory of Medical Genetics, Central South University, Changsha, China.
Beisha TangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Hong JiangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple system atrophy (MSA) is a fatal neurodegenerative disease, and the pathogenesis is still quite challenging. Emerging evidence has shown that the brain-gut-microbiota axis served a pivotal role in neurological diseases; however, researches utilizing metagenomic sequencing to analyze the alteration in gut microbiota of MSA patients were quite rare. Here, we carried out metagenomic sequencing in feces of 15 MSA patients and 15 healthy controls, to characterize the alterations in gut microbial composition and function of MSA patients in mainland China. The results showed that gut microbial community of MSA patients was significantly different from healthy controls, characterized by increased genus

Indexed as

functional pathwaysinflammationmetagenomicsmicrobiotamultiple system atrophy

Identifiers

PMID31680836
PMCPMC6813281
OpenAlexW2980361101

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.