ArticleFrontiers in neuroscience2019
Functional Connectivity Patterns and the Role of 5-HTTLPR Polymorphism on Network Architecture in Female Patients With Anorexia Nervosa.
Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain networks in eating disorders: a systematic review of graph theory studies.Eating and weight disorders : EWD · 2022Pooled it
- Functional network reorganization after magnetic resonance-guided focused ultrasound thalamotomy in tremor-dominant Parkinson's disease patients.NeuroImage. Clinical · 2026Article
- Functional network reorganization following VIM-MRgFUS for essential tremor.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Complex functional brain network properties in anorexia nervosa.Journal of eating disorders · 2022Article
- Shift Toward Randomness in Brain Networks of Patients With Anorexia Nervosa: The Role of Malnutrition.Frontiers in neuroscience · 2021Article
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6 authors.
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Abstract
introductionRecent neuroimaging studies suggest that anorexia nervosa (AN) symptoms emerge from failures in the relationships between spatially distributed networks that support different cognitive, emotional, and somatosensory functions. The 5-HTTLPR genotype has been shown to modulate all these abilities in AN, as well as the connectivity patterns between brain regions that support their functioning. This study aims at exploring the presence of any difference in functional connectome properties between AN patients and healthy controls (HC) by means of graph theory tools. The effect of 5-HTTLPR genotype on regional and global network characteristics in AN and HC was also explored.
methodsA sample of 74 subjects (38 HC, 36 AN) underwent a resting state functional magnetic resonance imaging and was genotyped for 5-HTTLPR polymorphism. Comparisons of network properties were made between the AN and HC groups and, within each group, between 5-HTTLPR carriers of low-functioning alleles and carriers of the long-long genotype.
resultsPatients with AN displayed lower network clustering than HC ( DISCUSSION: Patients with AN showed differences in hubs distribution, providing evidence of the presence of a different functional architectural backbone in this group. Since some correlation emerged between different degree values of nodes and differences in volumes, further longitudinal studies are warranted to better understand the role of malnutrition on brain network architecture. The opposite effects of 5-HTTLPR polymorphism on global network characteristics in the two groups suggest an interaction of the short allele and malnutrition in modulating brain network properties.
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