Evidence map›Paper›PMID 31680734›Full record

ArticleJournal of orthopaedics

MRI-biochemical follow up measurements of lumbar intervertebral disc in patients with leg length discrepancy: Is it possible to alter cartilage damage with conservative therapy?

Miriam Frenken, David Latz, Erik Schiffner, Wolfgang Alois Quante, Maxime Knautz, Daniel Benjamin Abrar, Benedikt Schaarschmidt, Christoph Schleich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Miriam FrenkenDepartment for Diagnostic and Interventional Radiology and University Hospital Dusseldorf, Heinrich-Heine-University, Dusseldorf, Germany.
David LatzDepartment of Trauma and Hand Surgery, University Hospital Dusseldorf, Heinrich-Heine-University, Dusseldorf, Germany.
Erik SchiffnerDepartment of Trauma and Hand Surgery, University Hospital Dusseldorf, Heinrich-Heine-University, Dusseldorf, Germany.
Wolfgang Alois QuanteDepartment of Trauma and Hand Surgery, University Hospital Dusseldorf, Heinrich-Heine-University, Dusseldorf, Germany.
Maxime KnautzDepartment for Diagnostic and Interventional Radiology and University Hospital Dusseldorf, Heinrich-Heine-University, Dusseldorf, Germany.
Daniel Benjamin AbrarDepartment for Diagnostic and Interventional Radiology and University Hospital Dusseldorf, Heinrich-Heine-University, Dusseldorf, Germany.
Benedikt SchaarschmidtDepartment for Diagnostic and Interventional Radiology and University Hospital Dusseldorf, Heinrich-Heine-University, Dusseldorf, Germany.
Christoph SchleichDepartment for Diagnostic and Interventional Radiology and University Hospital Dusseldorf, Heinrich-Heine-University, Dusseldorf, Germany.
Heinrich Heine University Düsseldorf · DEDüsseldorf University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEffect of conservative therapy on intervertebral discs (IVD) in patients with leg-length-discrepancy (LLD). M&M: Seventy lumbar IVDs of 14 participants (five with LLD 10-20 mm) were examined using a 3T-MRI-scanner. Morphological (Pfirrmann) and molecular (glycosaminoglycan-chemical-exchange-saturation-transfer, gagCEST) grading was assessed before and after a four-month therapy (physiotherapy and shoe inlays).

resultsSignificantly lower GAG values in patients with LLD were found (L5/S1, p = 0.02). After therapy, a trend towards higher gagCEST values in patients with LLD was observed (2.48 ± 1.77% vs. 1.79 ± 0.79%; p > 0.05).

conclusionLLD represents a risk factor for molecular alterations of lumbar IVDs. Only minor effects of conservative therapy on these alterations could be found.

Indexed as

Contrast-free MRIFollow-up analysisGagCESTLeg length discrepancyLumbar spineMolecular imagingMolecular MRI

Identifiers

PMID31680734
PMCPMC6818381
OpenAlexW2948836334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.