ArticleJournal of multivariate analysis2019
A semiparametric efficient estimator in case-control studies for gene-environment independent models.
Article in Journal of multivariate analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Hereditary and breastfeeding factors are positively associated with the aetiology of mammary gland hyperplasia: a case-control study.International health · 2021Article
- Article
- Semiparametrically efficient estimation in quantile regression of secondary analysis.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2018Article
- Dimension reduction and estimation in the secondary analysis of case-control studies.Electronic journal of statistics · 2018Article
- Semiparametric analysis of complex polygenic gene-environment interactions in case-control studies.Biometrika · 2017Article
- Semiparametric Estimation in the Secondary Analysis of Case-Control Studies.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2016Article
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Authors and funding
3 authors.
Funding
Abstract
Case-controls studies are popular epidemiological designs for detecting gene-environment interactions in the etiology of complex diseases, where the genetic susceptibility and environmental exposures may often be reasonably assumed independent in the source population. Various papers have presented analytical methods exploiting gene-environment independence to achieve better efficiency, all of which require either a rare disease assumption or a distributional assumption on the genetic variables. We relax both assumptions. We construct a semiparametric estimator in case-control studies exploiting gene-environment independence, while the distributions of genetic susceptibility and environmental exposures are both unspecified and the disease rate is assumed unknown and is not required to be close to zero. The resulting estimator is semiparametric efficient and its superiority over prospective logistic regression, the usual analysis in case-control studies, is demonstrated in various numerical illustrations.
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