ArticleJournal of visualized experiments : JoVE2019
Biomechanical Testing of Murine Tendons.
Article in Journal of visualized experiments : JoVE, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Pooled it
- Comparative Analysis of Tendon Healing in a Clinically Relevant Mouse Model of Achilles Tendon Repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Glycosaminoglycans influence regional mechanics in young but not old Achilles tendons.The Journal of physiology · 2025Article
- Dynamic transcriptional and epigenetic changes define postnatal tendon growth.PLoS genetics · 2025Article
- Multicellular muscle-tendon bioprinting of mechanically optimized musculoskeletal bioactuators with enhanced force transmission.Science advances · 2025Article
- Musculoskeletal architecture of the shoulder: A comparative anatomy study in bats and mice informing human rotator cuff function.bioRxiv : the preprint server for biology · 2025Article
- Functional tendon regeneration is driven by regulatory T cells and IL-33 signaling.Science advances · 2025Article
- Development of a Mouse Model of Enthesis-Specific NF-κB Activation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Tenascin C deletion impairs tendon healing and functional recovery after rotator cuff repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Tenascin C Deletion Impairs Tendon Healing and Functional Recovery After Rotator Cuff Repair.bioRxiv : the preprint server for biology · 2024Article
- A role for TGFβ signaling in Gli1+ tendon and enthesis cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Hedgehog Activation for Enhanced Rotator Cuff Tendon-to-Bone Healing.The American journal of sports medicine · 2023Article
- Preclinical tendon and ligament models: Beyond the 3Rs (replacement, reduction, and refinement) to 5W1H (why, who, what, where, when, how).Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Review
- Guidelines for ex vivo mechanical testing of tendon.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Review
- Optogenetic-induced muscle loading leads to mechanical adaptation of the Achilles tendon enthesis in mice.Science advances · 2023Article
- Recent Methods for Modifying Mechanical Properties of Tissue-Engineered Scaffolds for Clinical Applications.Biomimetics (Basel, Switzerland) · 2023Review
- Optogenetic-Induced Muscle Loading Leads to Mechanical Adaptation of the Achilles Tendon Enthesis in Mice.bioRxiv : the preprint server for biology · 2023Article
- Tendon progenitor cells as biological augmentation improve functional gait and reduce scar formation after rotator cuff repair.Journal of shoulder and elbow surgery · 2022Article
- The role of loading in murine models of rotator cuff disease.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Electrospun aligned poly(ε-caprolactone) nanofiber yarns guiding 3D organization of tendon stem/progenitor cells in tenogenic differentiation and tendon repair.Frontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Tendon disorders are common, affect people of all ages, and are often debilitating. Standard treatments, such as anti-inflammatory drugs, rehabilitation, and surgical repair, often fail. In order to define tendon function and demonstrate efficacy of new treatments, the mechanical properties of tendons from animal models must be accurately determined. Murine animal models are now widely used to study tendon disorders and evaluate novel treatments for tendinopathies; however, determining the mechanical properties of mouse tendons has been challenging. In this study, a new system was developed for tendon mechanical testing that includes 3D-printed fixtures that exactly match the anatomies of the humerus and calcaneus to mechanically test supraspinatus tendons and Achilles tendons, respectively. These fixtures were developed using 3D reconstructions of native bone anatomy, solid modeling, and additive manufacturing. The new approach eliminated artifactual gripping failures (e.g., failure at the growth plate failure rather than in the tendon), decreased overall testing time, and increased reproducibility. Furthermore, this new method is readily adaptable for testing other murine tendons and tendons from other animals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.