ArticleJournal of feline medicine and surgery2020
Assessment of treatment outcomes in hyperthyroid cats treated with an orally administered fixed dose of radioiodine.
Article in Journal of feline medicine and surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Change in insulin-like growth factor type 1 concentration after radioactive iodine treatment in cats with hyperthyroidism.Journal of feline medicine and surgery · 2025Article
- Radioactive iodine dose and survival in cats with hyperthyroidism (2015-2020).Journal of feline medicine and surgery · 2022Article
- Hyperthyroid cats and their kidneys: a literature review.Australian veterinary journal · 2022Review
- The effect of per os vs subcutaneousJournal of veterinary internal medicine · 2021Article
- A dosing algorithm for individualized radioiodine treatment of cats with hyperthyroidism.Journal of veterinary internal medicine · 2021Article
- Treatment failure in hyperthyroid cats after radioiodine (I-131) injection.Journal of veterinary internal medicine · 2021Article
- Assessment of serum symmetric dimethylarginine and creatinine concentrations in hyperthyroid cats before and after a fixed dose of orally administered radioiodine.Journal of veterinary internal medicine · 2020Article
- In clinically hyperthyroid cats, is I-131 treatment superior to thyroidectomy in normalising serum T4 level?Veterinary evidenceReview
- Outcome of radioiodine therapy for feline hyperthyroidism: Fixed dose versus individualized dose based on a clinical scoring system.Open veterinary journalArticle
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aims of this study were to describe the treatment outcomes following oral administration of a fixed dose (138 MBq; 3.7 mCi) of radioiodine in hyperthyroid cats and to examine the correlation between total thyroxine (TT4) concentrations before and after treatment.
methodsThis was a retrospective cohort study that documented the TT4 concentration and clinicopathological parameters at the time of diagnosis and after treatment. Logistic regression was used to assess the relationship between TT4 concentrations before and after treatment. The difference in pre- and post-treatment variables between cats that had TT4 concentrations below or within the reference interval (RI) was compared by the Mann-Whitney U-test.
resultsOf 161 cats, 133 (82.6%) cats had TT4 concentrations within the RI, four (2.5%) cats had TT4 concentrations above the RI and 24 (14.9%) cats had TT4 concentrations below the RI after treatment. The severity of hyperthyroidism at diagnosis, as measured by the percentage of TT4 elevation above the upper limit of the RI, had no impact on the odds of cats having low TT4 concentrations after treatment (odds ratio 1.00; 95% confidence interval 0.96-1.05; CONCLUSIONS AND RELEVANCE: When using an orally administered fixed dose of radioiodine for the treatment of feline hyperthyroidism, TT4 concentrations at diagnosis cannot be used to predict TT4 concentrations after treatment. The proportion of cats with TT4 concentrations below the lower limit of the RI after treatment was 14.9%. Further work is required to optimise oral radioiodine dosing to achieve maximal euthyroid outcomes.
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