ArticleChembiochem : a European journal of chemical biology2019
Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119.
Article in Chembiochem : a European journal of chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Development of a Genetically Encoded and Potent PDE6D Inhibitor.Chembiochem : a European journal of chemical biology · 2025Article
- The relationship between intraflagellar transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2024Article
- Targeting intracellular protein-protein interactions with macrocyclic peptides.Trends in pharmacological sciences · 2022Review
- Bicyclic β-Sheet Mimetics that Target the Transcriptional Coactivator β-Catenin and Inhibit Wnt Signaling.Angewandte Chemie (International ed. in English) · 2021Article
- Structural optimization of reversible dibromomaleimide peptide stapling.Peptide science (Hoboken, N.J.) · 2021Article
- A protein tertiary structure mimetic modulator of the Hippo signalling pathway.Nature communications · 2020Article
- Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119.Chembiochem : a European journal of chemical biology · 2019Article
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12 authors.
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Abstract
The acyl-binding UNC119 proteins mediate the activation and transport of various N-myristoylated proteins. In particular, UNC119a plays a crucial role in the completion of cytokinesis. Herein, we report the use of a lipidated peptide originating from the UNC119 binding partner Gnat1 as the basis for the design of lipidated, stabilized α-helical peptides that target UNC119a. By using the hydrocarbon peptide-stapling approach, cell-permeable binders of UNC119a were generated that induced the accumulation of cytokinetic and binucleated cells; this suggests UNC119a as a potential target for the inhibition of cytokinesis.
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