ArticleImmunology and cell biology2020
Characterization of the γδ T-cell compartment during infancy reveals clear differences between the early neonatal period and 2 years of age.
Article in Immunology and cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Perinatal γδ T cells: between invariance and diversity.Frontiers in immunology · 2026Review
- The immune system of preterm infants: an overview.Frontiers in immunology · 2026Review
- The immune response to human cytomegalovirus: impact of age, co-morbidities and the significance of anti-viral activity assessment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Immune development differs between preterm newborns fed mothers' own milk and donor milk.iScience · 2025Article
- Pre-T cell receptor-α immunodeficiency detected exclusively using whole genome sequencing.NPJ genomic medicine · 2025Article
- γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsis.The Journal of experimental medicine · 2024Article
- Bone Marrow-Suppressive Treatment in Children Is Associated with Diminished IFN-γ Response from T Cells upon Polyclonal and Varicella Zoster Virus Peptide Stimulation.International journal of molecular sciences · 2024Article
- Natural killer cells and innate lymphoid cells but not NKT cells are mature in their cytokine production at birth.Clinical and experimental immunology · 2024Article
- Role of innate T cells in necrotizing enterocolitis.Frontiers in immunology · 2024Review
- γδ T cells: origin and fate, subsets, diseases and immunotherapy.Signal transduction and targeted therapy · 2023Review
- Pediatric Brain Tumours: Lessons from the Immune Microenvironment.Current oncology (Toronto, Ont.) · 2023Review
- Four-Parameter FluoroSpot Assay Reveals That the Varicella Zoster Virus Elicits a Robust Memory T Cell IL-10 Response throughout Childhood.Journal of virology · 2022Article
- Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis.Nature communications · 2022Article
- Evidence for an Adult-Like Type 1-Immunity Phenotype of Vδ1, Vδ2 and Vδ3 T Cells in Ghanaian Children With Repeated Exposure to Malaria.Frontiers in immunology · 2022Article
- The Neonatal Innate Immune Response to Sepsis: Checkpoint Proteins as Novel Mediators of This Response and as Possible Therapeutic/Diagnostic Levers.Frontiers in immunology · 2022Review
- The adaptive immune system in early life: The shift makes it count.Frontiers in immunology · 2022Review
- Characterization of Adaptive-like γδ T Cells in Ugandan Infants during Primary Cytomegalovirus Infection.Viruses · 2021Article
- Age-related changes in PD-1 expression coincide with increased cytotoxic potential in Vδ2 T cells during infancy.Cellular immunology · 2021Article
- Extreme prematurity and sepsis strongly influence frequencies and functional characteristics of circulating γδ T and natural killer cells.Clinical & translational immunology · 2021Article
- A Cell for the Ages: Human γδ T Cells across the Lifespan.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
γδ T cells are unconventional T cells that function on the border of innate and adaptive immunity. They are suggested to play important roles in neonatal and infant immunity, although their phenotype and function are not fully characterized in early childhood. We aimed to investigate γδ T cells in relation to age, prematurity and cytomegalovirus (CMV) infection. Therefore, we used flow cytometry to characterize the γδ T-cell compartment in cord blood and peripheral blood cells from 14-day-, 2-year- and 5-year-old children, as well as in peripheral blood samples collected at several time points during the first months of life from extremely premature neonates. γδ T cells were phenotypically similar at 2 and 5 years of age, whereas cord blood was divergent and showed close proximity to γδ T cells from 14-day-old neonates. Interestingly, 2-year-old children and adults showed comparable Vδ2
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