ArticleClinical oral investigations2020
Vitamin D and hematinic deficiencies in patients with recurrent aphthous stomatitis.
Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Vitamin D status among apparently healthy individuals in the UAE: a systematic review.Frontiers in nutrition · 2025Pooled it
- Hematological parameters in patients with recurrent Aphthous Stomatitis: a systematic review and meta-analysis.BMC oral health · 2024Pooled it
- Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis.Frontiers in nutrition · 2023Pooled it
- How Nutrient Deficiencies Impact the Oral Mucosa and How to Manage Them: A Narrative Review.Nutrients · 2026Review
- Obesity, Lifestyle Habits and Nutrients in Relation to Oral Ulcers: A Comprehensive Mendelian Randomization Study.Health science reports · 2026Article
- Changes in Th1/Th2-related cytokine expression in the saliva of patients with recurrent aphthous stomatitis before and after prednisone treatment.Clinical oral investigations · 2022Article
- Detection and Analysis of the Oral Flora in Patients with Recurrent Aphthous Stomatitis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Salivary proteome of aphthous stomatitis reveals the participation of vitamin metabolism, nutrients, and bacteria.Scientific reports · 2021Article
- Relationship between dietary factors and recurrent aphthous stomatitis in China: a cross-sectional study.The Journal of international medical research · 2021Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectivesRecurrent aphthous stomatitis (RAS) represents a dysfunction in focal inflammatory processes. With the emerging anti-inflammatory roles of vitamin D (VD), we wanted to investigate the association between the onset and severity of RAS and serum VD level.
methodsFifty-two RAS cases and sex and age-matched controls were screened for serum iron, B
resultsVD was deficient in 53% of the study population with no statistically significant difference between the RAS patients and healthy controls (53.6 versus 51.5 nmol/l, respectively). In comparison with controls, RAS patients had lower means of iron (81.0 versus 89.3 μg/dl), vitamin B
conclusionsVD deficiency appears to have a role in aggravating RAS ulcerative episodes, but not their onset. CLINICAL RELEVANCE: Multiple aphthous ulcers might represent a subcategory of RAS lesions in which VD deficiency plays a role in aggravating the oral ulcerative condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.