ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2020
Atlantoaxial dislocation due to os odontoideum in patients with Down's syndrome: literature review and case reports.
Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 18 citations in OpenAlex.
- A Silent Threat: Acute Respiratory Failure and Os Odontoideum in a Child With Down's Syndrome.Cureus · 2025Article
- Atlantoaxial Instability due to Os Odontoideum in a Child with Christianson Syndrome.Molecular syndromology · 2024Article
- Database Review of 514 Patients with Os Odontoideum. Detailed Analysis of 258 Surgically Treated (1978-2019).Advances and technical standards in neurosurgery · 2024Article
- Grisel's syndrome and Down syndrome: a case report.International journal of burns and trauma · 2023Article
- Treatment of Atlantoaxial Dislocation in Children with Down Syndrome Using Posterior Atlantoaxial Screw Fixation.Frontiers in surgery · 2022Article
- Letter to the editor regarding "Atlantoaxial dislocation due to os odontoideum in patients with Down's syndrome: literature review and case reports".Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Evaluation of 2011 AAP cervical spine screening guidelines for children with Down Syndrome.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Review
- Os odontoideum: A comprehensive review.Journal of craniovertebral junction & spineReview
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo clarify etiology, clinical features, and diagnostic and treatment options of atlantoaxial dislocation (AAD) due to os odontoideum (OsO) in patients with Down's syndrome (DS).
methodsWe described and analyzed three clinical cases of AAD due to OsO in DS patients and reviewed descriptions of similar cases in the scientific sources.
resultsAccording to literature review, more than 80% of DS patients with odontoid ossicles had atlantoaxial instability (AAI). AAI in DS patients with OsO is more often manifested in childhood and adolescence, rarely in adults when ligament relaxation is reduced. Some patients had acute clinical manifestation after a minor trauma without any precursors; in some of the cases, neurological deterioration increased during several years. We found that the earlier surgical treatment of AAD due to OsO in DS patients carries the higher recovery potential.
conclusionsMost patients with DS and OsO had AAI. The method of appropriate treatment in such cases is a posterior screw fixation. Preoperative halo traction and posterior fusion have proved to be a very useful tool in the treatment of AAD due to OsO in DS patients. Even if irreducibility of the AAD established preoperatively, it should not be an absolute indication for anterior decompression. In such cases, an attempt to reduce the AAD should be made under general anesthesia during posterior fixation.
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