Evidence map›Paper›PMID 31680196›Full record

ArticleNeuroradiology2020

Visual pathways evaluation in Kearns Sayre syndrome: a diffusion tensor imaging study.

Maria Camilla Rossi-Espagnet, Martina Lucignani, Luca Pasquini, Antonio Napolitano, Stefano Pro, Andrea Romano, Daria Diodato, Diego Martinelli, Daniela Longo

Abstract read
PubMed Publisher
In one paragraph

Article in Neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. In Vivo Brain GSH: MRS Methods and Clinical Applications.Antioxidants (Basel, Switzerland) · 2021
    Review
  4. Observational
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Maria Camilla Rossi-EspagnetNeuroradiology Unit, Imaging Department, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00100, Rome, Italy. mcamilla.rossi@opbg.net.ORCID https://orcid.org/0000-0002-2991-5840
Martina LucignaniMedical Physics Department, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Luca PasquiniNeuroradiology Unit, Imaging Department, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00100, Rome, Italy.
Antonio NapolitanoMedical Physics Department, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Stefano ProNeurology Unity, Department of Neurosciences, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Andrea RomanoNESMOS Department, Sant'Andrea Hospital, Sapienza University, Rome, Italy.
Daria DiodatoUnit of Neuromuscular and Neurodegenerative Disorders, Laboratory of Molecular Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Diego MartinelliDivision of Metabolism and Research Unit of Metabolic Biochemistry, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Daniela LongoNeuroradiology Unit, Imaging Department, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00100, Rome, Italy.
Bambino Gesù Children's Hospital · ITPoliclinico Umberto I · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeKearns Sayre syndrome (KSS) is a mitochondrial disorder characterized by development of visual impairment. Electroretinogram (ERG) and visual evoked potentials are not able to provide topographical information of optic damage. The purpose of this study was to explore retrochiasmatic optic pathway alteration in KSS with diffusion tractographic analysis and to compare it with different tracts.

methodsDTI from 8 KSS subjects (14.7 years) and 10 healthy controls (HC) were acquired on a 3T scanner. Optic radiations (OR), optic tracts (OT), inferior frontooccipital fasciculus (IFOF) and corticospinal tract (CST) were reconstructed with probabilistic tractography. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), radial (RD), and axial diffusivity (AD) were calculated, evaluating group differences. T test on diffusion parameters identified significantly different track portions among cohorts.

resultsAll patients had optic pathway alterations at electrophysiological examination. Significant lower FA were found in OT, IFOF, and CST of KSS group. RD was significantly higher in bilateral OR, IFOF, CST, and right OT, while ADC was higher in bilateral OR and CST. RD values were higher in the proximal and distal portion of OR bilaterally and in the distal portion of right OT, while widespread differences were found in IFOF and CST. No significant differences were found for AD. FA profiles analysis demonstrated significant differences between groups in several regions of OT, IFOF, and CST, while ADC assessment revealed spread differences in OR and CST.

conclusionsDTI evaluation of retrochiasmatic tracks may represent a useful tool to topographically investigate retrochiasmatic visual impairment in KSS.

Indexed as

AdolescentAnisotropyCase-Control StudiesDiffusion Tensor ImagingEvoked Potentials, VisualFemaleHumansImage Interpretation, Computer-AssistedKearns-Sayre SyndromeMalePyramidal TractsVisual PathwaysDiffusion tensor imagingKearns Sayre syndromeLeukodystrophyMitochondrial disordersOptic pathway

Identifiers

PMID31680196
OpenAlexW2987560508

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.